What causes production of agglutinins?
A body might produce agglutinins to attack the erythrocytes due to allergies to foods, inhalants, chemicals and infections. A person suffering from this condition will likely have cooler body parts such as fingers, nose, and ears attacked more often than warmer areas such as armpits.
What diseases can cause cold agglutinins?
Secondary cold agglutinin disease may be associated with:
- Bacterial Infections such as mycoplasma, Legionnaires’ disease, syphilis, listeriosis, or E.
- Viral infections such Epstein-Barr virus, cytomegalovirus, mumps, varicella, rubella, adenovirus, HIV, influenza, or hepatitis C.
Why does cold agglutinin happen?
Your body’s immune system makes proteins called antibodies that help you fight off infections. Some of these antibodies are called cold agglutinins because they’re triggered when your body’s temperature is below normal.
What are the symptoms of cold agglutinin disease?
Symptoms of cold agglutinin disease (CAD) can be triggered or worsened by cold temperatures or viral infections and most people with cold agglutinin disease have symptoms of hemolytic anemia such as fatigue, dizziness, headaches, cold hands and feet, pale skin, dark urine, yellowing skin and eyes (jaundice), chest pain …
What causes white blood cells to clump together?
Conditions that cause high WBC values include infection, inflammation, damage to body tissues (such as a heart attack), severe physical or emotional stress (such as a fever, injury, or surgery), kidney failure, lupus, tuberculosis (TB), rheumatoid arthritis, malnutrition, leukemia, and diseases such as cancer.
Is Cold agglutinin disease an autoimmune disease?
INTRODUCTION Cold agglutinin disease (CAD) is a form of autoimmune hemolytic anemia (AIHA) in which cold agglutinins (agglutinating autoantibodies with an optimum temperature of 3 to 4°C) can cause clinical symptoms related to agglutination of red blood cells in cooler parts of the body and hemolytic anemia.
What is Agglutinogen and agglutinin?
Agglutinins are specific antibody proteins that attack invading pathogens, and agglutinogens are the cells, toxins, bacteria, and foreign entities recognized by the immune system.
Can cold agglutinin go away?
Can cold agglutinin disease be cured? In cases of secondary cold agglutinin disease caused by bacterial or viral infections, the symptoms typically go away on their own within 6 months after the bacterial or viral infection has resolved.