What does a high alpha-1 globulin mean?
High alpha-1 globulin: Infection; inflammation. High alpha-2 globulin: Inflammation; kidney disease. High beta globulin: Very high cholesterol; low iron (iron-deficiency anemia) High gamma globulin: Inflammation; infection; liver disease; some forms of cancer.
What are alpha-1 globulins?
α1 globulins. They comprise: α1-antiproteinase or α1-antitrypsin is a glycoprotein with a mass of 50 kDa and a total carbohydrate content of 12%. It is one of the main inhibitors of plasma serine proteases, protecting tissues (especially the lung) from the action of proteases released by polymorphonuclear granulocytes.
What does it mean when alpha-2 globulin is high?
Increased alpha-2 globulin proteins may indicate a: Acute inflammation. Chronic inflammation.
What does it mean if your albumin globulin ratio is high?
High A/G ratio: This can be a sign of disease in your liver, kidney, or intestines. It’s also linked to low thyroid activity and leukemia. If your doctor feels any of your levels are too high or low, you may need to have more precise blood or urine tests.
What are the symptoms of high globulin?
Investigating the cause of a raised globulin level
- Bone pain (myeloma).
- Night sweats (lymphoproliferative disorders).
- Weight loss (cancers).
- Breathlessness, fatigue (anaemia).
- Unexplained bleeding (lymphoproliferative disorders).
- Symptoms of carpal tunnel syndrome (amyloidosis).
- Fever (infections).
What does it mean when your alpha-1 globulin is low?
Low globulin levels can be a sign of liver or kidney disease. High levels may indicate infection, inflammatory disease or immune disorders. High globulin levels may also indicate certain types of cancer, such as multiple myeloma, Hodgkin’s disease, or malignant lymphoma.
What is the function of alpha globulin?
Alpha globulins are a group of globular proteins in plasma that are highly mobile in alkaline or electrically charged solutions. They inhibit certain blood proteases and show significant inhibitor activity.
What happens if globulin is high?
High levels may indicate infection, inflammatory disease or immune disorders. High globulin levels may also indicate certain types of cancer, such as multiple myeloma, Hodgkin’s disease, or malignant lymphoma. However, abnormal results may be due to certain medications, dehydration, or other factors.
Is a 1.0 A G ratio bad?
In general, an albumin/globulin ratio between 1.1 and 2.5 is considered normal, although this can vary depending on the laboratory performing the test [4]. Your blood usually contains a little more albumin than globulin, which is why a normal ratio is slightly higher than 1 [1].
What infections cause high protein in blood?
What causes high blood protein?
- Dehydration.
- Chronic (long-term) inflammation or inflammatory disorders.
- Infections caused by viruses, such as hepatitis B, hepatitis C or HIV/AIDS.
- Certain cancers, like multiple myeloma, sarcoidosis and Waldenstrom macroglobulinemia.
- Severe liver or kidney disease.
What is the normal range of alpha 1 globulin in serum?
Alpha-1-Globulin, Serum. Optimal Result: 0 – 0.4 g/dL. Protein in the serum is made up of albumin (∼ 60%) and globulin. Globulins are divided into alpha-1, alpha-2, beta, and gamma globulins. Globulins are made in your liver by your immune system. They play an important role in liver function, blood clotting, and fighting infection.
What are alpha and gamma globulins and why are they important?
Globulins are made in your liver by your immune system. They play an important role in liver function, blood clotting, and fighting infection. In general, alpha and gamma globulin protein levels increase when there is inflammation in the body. Chronic inflammatory disease (for example, rheumatoid arthritis, SLE)
What causes increased alpha-1 globulin protein levels?
Increased alpha-1 globulin proteins may be due to: Acute inflammatory disease; Chronic inflammatory disease (for example, rheumatoid arthritis, SLE) Cancer