What does CD138 positive mean?

What does CD138 positive mean?

CD138 is a classic plasma cell marker and can be found on both normal polyclonal or abnormal monoclonal plasma cells. Being CD138 positive and knowing the total plasma cell % from the core bone specimin would be the best markers to understand the extent of bone marrow infiltration.

What is CD38 and CD138?

Abstract. Background/Aim: CD38 is a cell surface marker commonly present in plasma cells and activated T cells, while CD138 is a representative plasma cell marker.

What is CD138 in multiple myeloma?

Syndecan-1 or CD138, is a heparan-sulfate coated glycoprotein, which is highly expressed on the surface of plasma cells and myeloma cells, important for adhesion and accumulating survival signals.

What does CD138 negative mean?

Endometrial CD138 count appears to be a negative prognostic indicator for patients who have experienced previous embryo transfer failure – Fertility and Sterility.

What is CD138 positive plasma cells?

During normal B-cell development, cells acquire expression of CD138, also known as syndecan-1 (SDC1), a marker highly specific for terminally differentiated normal plasma cells (1). CD138 is a heparin sulphate proteoglycan that controls tumor cell survival, growth, adhesion and bone cell differentiation in MM (2).

What is CD138 a marker of?

Within the hematopoietic system, CD138 is an excellent marker of plasmacytic differentiation. Based on its broad staining profile, CD138 reactivity for neoplastic cells is not a definitive marker for plasmacytic derivation, unless a hematolymphoid origin has been established.

What are CD138 cells?

What is CD138 negative plasma cells?

CD138 negative plasma cells are a sub-population of malignant plasma cells (PCs) which may be more primitive and have a higher proliferative potential than CD138 positive plasma cells [1].

What is CD138 staining?

Is multiple myeloma benign or malignant?

Multiple myeloma almost always starts out as a relatively benign condition called monoclonal gammopathy of undetermined significance (MGUS). MGUS , like multiple myeloma, is marked by the presence of M proteins — produced by abnormal plasma cells — in your blood.

What does CD138 stand for?

The CD138 molecule is a transmembrane heparan sulphate glycoprotein expressed at distinct stages of differentiation in normal lymphoid cells such as pre-B cells, immature B cells and Ig-producing plasma cells as well as being expressed in stratified and simple epithelia.

What is cdcd138 ( syndecan1)?

CD138, also designated syndecan-1, is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. The syndecans’ main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration.

Is CD138 a definitive marker for plasmacytic derivation in neoplastic cells?

Based on its broad staining profile, CD138 reactivity for neoplastic cells is not a definitive marker for plasmacytic derivation, unless a hematolymphoid origin has been established. Biomarkers, Tumor / analysis Biomarkers, Tumor / metabolism

Is CD138 a receptor for extracellular matrix?

Integral membrane protein is a receptor for extracellular matrix Loss of CD138 expression is associated with tumor aggressiveness in squamous cell carcinoma (SCC) of head and neck and larynx; levels also reduced in invasive SCC but not in SCC in situ

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