What does paracoccidioidomycosis mean?
Paracoccidioidomycosis is an infection caused by the fungus Paracoccidioides. This fungus lives in parts of Central and South America. Anyone who lives in or visits areas where Paracoccidioides lives can get paracoccidioidomycosis, but it most often affects men who work outdoors in rural areas.
How is paracoccidioidomycosis diagnosed?
The diagnosis of paracoccidioidomycosis is usually made by examination of sputum or pus from infected individuals. If positive, microscopic examination will permit the identification of the responsible fungus, Paracoccidioides brasiliensis.
Where is paracoccidioides brasiliensis found?
The Paracoccidioides brasiliensis fungus is found in areas of Mexico and south to Argentina, with most cases in Brazil, Colombia, and Venezuela. Transmission can occur though inhalation of conidia. Primary infection is in the lungs, but spread to lymph nodes is common.
What disease does Paracoccidioidomycosis cause?
| Paracoccidioidomycosis | |
|---|---|
| Specialty | Infectious disease |
| Symptoms | Fever, sepsis, weight loss, large glands, large liver and spleen, mouth ulcers, skin lesions. |
| Types | Mucocutaneous, lymphatic, multi-organ |
| Causes | Paracoccidioides brasiliensis |
How do you say brasiliensis?
Phonetic spelling of Hevea brasiliensis
- bob. Nishi Handa.
- He-vea brasilien-sis.
- Hevea bra-si-li-en-sis. Bernice Berge.
What disease does paracoccidioidomycosis cause?
What is the drug of choice for Paracoccidioidomycosis?
Antifungal Treatment Itraconazole is considered the drug of choice for paracoccidioidomycosis, with a reported effectiveness of 95%. The course of therapy is typically 200 mg/day for 6 months.
What is Paracoccidioidomycosis (PCM)?
Paracoccidioidomycosis (PCM) is an acute to chronic fungal infection caused by fungi in the genus Paracoccidioides, including Paracoccidioides brasiliensis and Paracoccidioides lutzii. It is endemic to Central and South America, and is considered to be a neglected endemic mycosis, a type of neglected tropical disease.
What is the prevalence of Paracoccidioidomycosis in South America?
Paracoccidioidomycosis occurs only in discrete foci in South and Central America, most often in men aged 20 to 50, especially coffee growers of Colombia, Venezuela, and Brazil. An estimated 10 million people in South America are infected.
What is the pathophysiology of Paracoccidioides brasiliensis?
Although specific natural sites for Paracoccidioides brasiliensis remain undefined, it is presumed to exist in soil as a mold, with infection due to inhalation of conidia (spores produced by the mycelial form of the fungus). Conidia convert to invasive yeasts in the lungs and are assumed to spread to other sites via blood and lymphatics.
What is the treatment for Paracoccidioides?
Treatment. IV amphotericin B can also eliminate the infection and is often used in very severe cases. Sulfonamides, which are widely used in some countries because they are inexpensive, can suppress growth of Paracoccidioides and cause lesions to regress but are not curative and must be given for up to 5 yr.