What does PP2C mean?
Protein phosphatase 2C (PP2C) is a member of the metal-dependent protein phosphatases (PPMs). PP2C is a monomeric enzyme with at least four isoforms in human. Few targeting proteins have yet been identified and, to date, there are no PP2C inhibitors available.
What does PP2C do in cystic fibrosis?
PP2C has been implicated in the regulation of the stress-activated MAPK signaling cascade. Further neuronal functions of PP2C include dephosphorylation of metabotropic glutamate receptors (mGluR3) and interaction with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.
Where is PP2C expressed in the brain?
PP2C is expressed in the brain, and likely neuronal substrates include the autophosphorylation site of CaMKII, the CK1 site on DARPP-32, and the PKA site on tyrosine hydroxylase (see below). PP2C has been implicated in the regulation of the stress-activated MAPK signaling cascade.
What is the role of protein phosphatase 2C?
Protein phosphatase 2C (PP2C) is a member of the metal-dependent protein phosphatases (PPMs). PP2C is a monomeric enzyme with at least four isoforms in human. Few targeting proteins have yet been identified and, to date, there are no PP2C inhibitors available. As a result, it has been difficult to examine the role of this phosphatase.