What does SHP2 do?
Shp2 promotes the growth of glioblastoma cells by suppressing cellular senescence 86. Shp2 and Stat5 function as proximal effectors of the Kit oncogene, and cell survival is driven by the Shp2/Erk pathway; conversely, G1/S transition during the cell cycle is accelerated by the Kit/Stat5 and Kit/PI3K/Akt pathways 87.
What does SHP2 stand for?
The Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) is an oncogenic phosphatase associated with various kinds of leukemia and solid tumors.
What is a SHP2 inhibitor?
An inhibitor of protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11), with potential antineoplastic activity. Upon oral administration, SHP2 inhibitor TNO155 binds to and inhibits SHP2.
What is PTP1B?
PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes. It has also been implicated in the development of breast cancer and has been explored as a potential therapeutic target in that avenue as well.
What is PTPN11 gene?
The PTPN11 gene provides instructions for making a protein called SHP-2. This protein helps regulate the RAS/MAPK signaling pathway.
What is tno155?
TNO 155 is an orally administered protein tyrosine phosphatase non-receptor type 11 (SHP2) inhibitor being developed by Novartis Pharmaceuticals, for the treatment of solid tumours including those harboring KRASG12C mutations such as colorectal cancer.
What chromosome is PTPN11 on?
PTPN11 is a protein tyrosine phosphatase (PTP) Shp2….
| PTPN11 | ||
|---|---|---|
| Location (UCSC) | Chr 12: 112.42 – 112.51 Mb | Chr 5: 121.13 – 121.19 Mb |
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| Wikidata | ||
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What is an example of Adaptor protein that has SH2 domain?
Examples of such adaptors include Nck, Crk, and Shc, as well as Grb2, which forms a complex with Sos, a nucleotide exchange molecule for Ras, and the regulatory subunit p85, which forms a complex with the catalytic subunit p110 of phosphatidylinositol 3′-kinase (PI3-kinase).
Does Ras protein have SH2 domain?
Ras, a small GTP-binding protein, is an important component of the signal transduction pathway used by growth factors to initiate cell growth and differentiation. Signaling proteins with Src homology 2 (SH2) domains then bind to these tyrosine-phosphorylated residues, initiating multiple signaling cascades.
What is SOS1 gene?
The SOS1 gene provides instructions for making a protein that is involved in controlling (regulating) the activation of the RAS/MAPK signaling pathway, which helps control several important cell functions.
Is SHP2 phosphatase an oncogenic protein?
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Subjects. Abstract. The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor signalling and was the first reported oncogenic tyrosine phosphatase.
Is SHP2 a therapeutic target in cancer?
The tyrosine phosphatase SHP2 is a key mediator of receptor tyrosine kinase (RTK) signalling, as well as being important in immune checkpoint pathways. Reduction of SHP2 activity suppresses tumour cell growth, and SHP2 is a potential, but so far elusive, therapeutic target in cancer.
What is the pathophysiology of SHP2?
Src homology region 2-containing protein tyrosine phosphatase 2 (Shp2) is associated with breast cancer, leukaemia, lung cancer, liver cancer, gastric cancer, laryngeal cancer, oral cancer and other cancer types. Signalling pathways involving Shp2 have also been discovered. Shp2 is related to many diseases.
How does targetshp099 bind to SH2?
SHP099 concurrently binds to the interface of the N-terminal SH2, C-terminal SH2, and protein tyrosine phosphatase domains, thus inhibiting SHP2 activity through an allosteric mechanism.