What is 6-mercaptopurine used for?
Mercaptopurine is used alone or with other chemotherapy drugs to treat acute lymphocytic leukemia (ALL; also called acute lymphoblastic leukemia and acute lymphatic leukemia; a type of cancer that begins in the white blood cells). Mercaptopurine is in a class of medications called purine antagonists.
What is thioguanine used for?
Thioguanine is used to treat acute myeloid leukemia (AML; a type of cancer that begins in the white blood cells). Thioguanine is in a class of medications known as purine analogs. It works by slowing or stopping the growth of cancer cells in your body.
What are thiopurine drugs?
The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn’s disease, rheumatoid arthritis), and organ transplant recipients. Metabolism is catalyzed by S-methyltransferase.
What is the TPMT enzyme?
Thiopurine methyltransferase (TPMT) is the main enzyme responsible for inactivating toxic products of azathioprine (AZA) metabolism. Patients with homozygous deficiency of this enzyme have no enzyme activity and ideally should not be given AZA.
Can you take paracetamol with mercaptopurine?
Paracetamol. Both mercaptopurine and paracetamol can increase the risk of hepatotoxicity.
What is fluorouracil used for?
Fluorouracil cream and topical solution are used to treat actinic or solar keratoses (scaly or crusted lesions [skin areas] caused by years of too much exposure to sunlight).
How do thiopurines work?
The thiopurines are immunosuppressive drugs, deactivating key processes in T lymphocytes that lead to inflammation. The process through which azathioprine and other thiopurines treat inflammatory diseases involves a complex set of genetic activities.
What does 6-TGN stand for?
6-thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine (me-MP) are metabolites of the thiopurines azathioprine and 6-mercaptopurine.
How many patients have been assessed using 6-TGN results?
We assessed all 6-TGN results in the database between March 2002 and December 2016, which represents approximately 10,000 patients. First, all pairs of 6-TGN and 6-MMP results were aggregated, and any single metabolite results were excluded. All result pairs giving a 6-TGN/6-MMP ratio >20 were identified.
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