What is a normal CD20 count?
Reference ranges for CD10, CD19, and CD20 were found to be 1–3 (median 1%), 6–23 (median 14%), and 6–23 (median 14%), respectively (Table 2).
What does low CD20 mean?
CD20 negative B cell non-Hodgkin lymphoma (NHL) is rare and accounts for approximately 1-2% of B cell lymphomas. CD20- negative NHL is frequently associated with extranodal involvement, atypical morphology, aggressive clinical behaviour, resistance to standard chemotherapy and poor prognosis.
What does a high CD20 count mean?
A protein found on B cells (a type of white blood cell). It may be found in higher than normal amounts in patients with certain types of B-cell lymphomas and leukemias. Measuring the amount of CD20 on blood cells may help to diagnose cancer or plan cancer treatment. CD20 is a type of tumor marker.
What is a CD20 positive B-cell?
Clinical Information CD20 (cluster of differentiate 20) is a protein that is expressed on the surface of B cells, starting at the pre-B cell stage and also on mature B cells in the bone marrow and in the periphery. CD20 is not expressed on hematopoietic stem cells, pro-B cells, or normal plasma cells.
Is CD20 positive normal?
CD20 positive T cell lymphoma is a rare condition that is characterized by the coexpression of CD20 and T cell markers, such as, CD3, CD5, or UCHL-11. Positivity for CD20 in any type of T cell lymphoma represents an aberrant immunophenotype, despite the presence of various indicators of T cell lymphoma.
What happens if your lymphocytes are low?
A low lymphocyte count makes it hard for your body to fight infections. You may get infections caused by viruses, fungi, parasites, or bacteria. Treatment for an infection will depend on its cause. You also may need treatment after an infection is gone to help prevent repeat infections.
Is rituximab a chemotherapy?
RITUXAN is not chemotherapy RITUXAN is a type of antibody therapy that can be used alone or with chemotherapy. They work in different ways to find and attack the cells where cancer starts.
What is CD20 positive non Hodgkin’s lymphoma?
The goal of CD20-targeted therapy is to kill B lymphocytes by the use of monoclonal antibodies (MoAb) against the B-cell specific human CD20 molecule. Clinical success started by targeting non-Hodgkin’s lymphoma (NHL) with rituximab, a chimeric anti-CD20 MoAb.
Do plasma cells express CD20?
CD20 is a trans-membrane protein expressed on mature B cells through all stages of their development. However, its expression is down regulated at the point of differentiation into plasma cells and expressed only in 16-22% of mature plasma cells.
Can autoimmune disease cause low lymphocytes?
Lymphopenia is not uncommon in several human autoimmune diseases. Reduced total lymphocyte counts are observed in rheumatoid arthritis, insulin-dependent diabetes mellitus, Crohn’s disease, systemic lupus erythematosus (SLE) and primary vasculitides.
What is CD20 (cluster of differentiate 20)?
CD20 (cluster of differentiate 20) is a protein that is expressed on the surface of B cells, starting at the pre-B cell stage and also on mature B cells in the bone marrow and in the periphery. CD20 is not expressed on hematopoietic stem cells, pro-B cells, or normal plasma cells. (1) Plasmablasts and stimulated plasma cells may express CD20.
What is cdcd20 and where is it expressed?
CD20 is a protein that is expressed on the surface of B cells, starting at the pre-B cell stage and also on mature B cells in the bone marrow and in the periphery.
Does CD20 deficiency affect B-cell differentiation?
This did not disturb precursor B-cell differentiation in the bone marrow, as the patient had normal serum IgM levels and normal B-cell numbers. However, CD20 deficiency resulted in a reduced number of circulating memory B cells, reduced isotype switching of Ig, and decreased IgG antibody levels.
Are CD20 deficient mice immune-deficient?
Initial analysis of CD20 deficient mice showed no immune-deficient phenotype [2,3], however, more recently CD20 deficient mice and humans were found to exhibit decreased T-independent immune responses [4]. Largely fuelled by the interest in CD20 as a tumor target, research on CD20 biology has intensified in the recent years.