What is a spindle cell pathology?
Spindle cells are specialized cells that are longer than they are wide. They are found both in normal, healthy tissue and in tumours. The most common type of normal spindle cell is called a fibroblast. Fibroblasts are support cells that are found in a type of connective tissue called stroma.
Is spindle cell malignant or benign?
Spindle cell carcinoma, also termed carcinosarcoma, pseudosarcoma, polypoid carcinoma, sarcomatoid carcinoma, and spindle cell variant of squamous cell carcinoma, is a rare type of malignant tumor that often grows as an exophytic polypoid lesion (see also Chapter 20).
What is spindle cell lung cancer?
Spindle cell carcinoma of the lung consists of only spindle-shaped tumor cells, and accounts for approximately 13.3% of all sarcomatoid carcinomas (SCs), which are a rare subtype of poorly differentiated non-small cell lung cancer (NSCLC).
What is a benign spindle cell tumor?
Benign spindle cell lesions of the breast encompass a wide and heterogeneous spectrum of fibroblastic and myofibroblastic tumor-like or tumor entities. 7, 8 By definition, they should be composed exclusively of spindle cells (pure spindle cell lesions), with no mixed epithelial component.
What is low grade spindle lesion?
Low-grade fibromatosis-like spindle cell carcinoma is a rare tumor in the breast, and represents a variant of the very heterogeneous group of metaplastic carcinomas of the breast.
Where do you find spindle cells?
Spindle cell sarcomas of the bone are often found in the arms, legs and pelvis. They most commonly arise in patients over the age of 40 and are extremely rare, making up just 2-5% of all primary bone cancer cases.
Is spindle cell carcinoma serious?
Background. Spindle cell carcinoma (SCC) is a highly malignant pulmonary sarcomatoid carcinoma. There is no standard treatment for this disease, though chemotherapy, surgery and radiation therapy may be considered.
Is spindle cell neoplasm cancerous?
Spindle cell sarcoma is a rare malignant (cancerous) tumour which can develop in the bone or soft tissue. It can arise in any part of the body but is most common in the limbs (arms and legs).
How are spindle cell tumors treated?
The usual treatment for spindle cell sarcoma is surgery to remove the tumour. Chemotherapy can be used in certain situations and we will discuss this with you we feel this is a suitable option.
Are bland spindle cells cancerous?
Bland-looking spindle cell lesions of the breast comprise a heterogeneous group of tumor-like and tumor entities, ranging from reactive to low-grade malignant neoplasms with metastatic potential 1.
What is a spindle cell lipoma?
Spindle cell lipoma is an uncommon variant of lipoma, characterized by mature adipocytes and small uniform spindle cells. The lesion usually presents in male patients between the age of 40 to 60, and is located in the subcutaneous layer of the posterior trunk, shoulder and posterior neck [1].
What are the different types of spindle cells?
A general introduction to spindle cells is found in the spindle cell article. Nerve. Muscle. Smooth. Skeletal. Other. Carcinoma, e.g. metaplastic carcinoma. Monomorphic – small variation of tumour cell size. Pleomorphic – large variation of tumour cell size.
What are the components of spindle cell lipoma?
Spindle cell lipoma typically contains three components: thin, uniform spindle cells arranged in short, parallel bundles, mature adipocytes and ropy birefringent collagen Pleomorphic tumors have prominent floret giant cells (hyperchromatic, multinucleated, wreath-like nuclei) and small round hyperchromatic cells
What is cutcutaneous spindle cell squamous carcinoma?
Cutaneous spindle cell squamous carcinoma is an uncommon variant of squamous cell carcinoma, in which (a) keratinocytes infiltrate dermis as single cells with elongated nuclei, not as cohesive nests or islands, and (b) there are no / minimal signs of keratinization of conventional squamous cell carcinoma ( Am J Dermatopathol 2008;30:228 )
Where can I find information on spindle cell hemangioma?
Spindle cell hemangioma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumornonmelanocytichemangiomaspindle.html. Accessed September 12th, 2021.