What is Angiolymphoid hyperplasia with eosinophilia?
Angiolymphoid hyperplasia with eosinophilia (ALHE), also named epithelioid hemangioma (EH), is an inflamed vascular tumefaction of uncertain pathogenesis, characterized by proliferation of histiocytoid endothelial cells with prominent lymphocytic and eosinophilic infiltration.
What is ALHE?
Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon, vasoproliferative, idiopathic condition that manifests in adults as isolated or grouped papules, plaques, or nodules in the skin of the head and neck. Most patients present with lesions in the skin of the periauricular region, forehead, or scalp.
What is reactive follicular hyperplasia?
Reactive follicular hyperplasia, Lymphoid nodular hyperplasia. Follicular hyperplasia (FH) is a type of lymphoid hyperplasia and is classified as a lymphadenopathy, which means a disease of the lymph nodes. It is caused by a stimulation of the B cell compartment and by abnormal cell growth of secondary follicles.
What causes Castleman disease?
It’s not clear what causes Castleman disease. However, infection by a virus called human herpesvirus 8 (HHV-8) is associated with multicentric Castleman disease. The HHV-8 virus has also been linked to the development of Kaposi’s sarcoma, a cancerous tumor that can be a complication of HIV/AIDS.
What does Castleman disease do to the body?
People with Castleman disease have an increased risk of developing cancers including lymphoma (cancer of the lymph system) and Kaposi’s sarcoma (a cancerous skin tumor). Some people with MCD develop infections that can damage organs and be life-threatening if they are not treated.
Is follicular hyperplasia serious?
Typically follicular hyperplasia is categorized as a benign lymphadenopathy. This is usually almost always treatable, but only until it progresses into malignancy.
How is Kimura’s disease diagnosed?
Kimura’s disease (also referred to as subcutaneous eosinophilic lymphoid granuloma) can be diagnosed with confidence under the right clinical context in endemic populations. It typically presents as painless soft tissue nodules (1-10cm in diameter). Small pink to red papules can also be present, singly or in multiples.
What is the relationship between Kimura’s disease and nephrotic syndrome?
Kimura’s disease is generally limited to the skin, lymph nodes, and salivary glands, but patients with Kimura’s disease and nephrotic syndrome have been reported. The basis of this possible association is unclear.
What is extranodal Kimura disease?
In 1948, Kimura described it as “unusual granulation combined with hyperplastic changes in lymphoid tissue”; subsequently, this process was widely known as Kimura disease ( Am J Otolaryngol 2017;38:626 ) Extranodal commonly includes skin and subcutaneous tissue, head and neck sites, including major salivary glands
What is the eosinophil concentration of Kimura?
He had an eosinophil concentration of 36% (absolute count: 8172/ml), his IgE level was 9187 IU/ml. He was diagnosed with Kimura’s disease. Initially treated with corticosteroids, he was given a single dose of intravenous immunoglobulin (IVIG) as a steroid-sparing agent after the disease flared while tapering prednisone.
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