What is cathepsin K inhibitor?

What is cathepsin K inhibitor?

Cathepsin K is a cysteine protease member of the cathepsin lysosomal protease family. Compared with other antiresorptive agents, cathepsin K inhibition is nearly equally efficacious for reducing biochemical markers of bone resorption but comparatively less active for reducing bone formation markers.

What does cathepsin K do?

Cathepsin K is a protease, which is defined by its high specificity for kinins, that is involved in bone resorption. The enzyme’s ability to catabolize elastin, collagen, and gelatin allows it to break down bone and cartilage.

What inhibits bone resorption?

Calcitonin is a hormone secreted by the thyroid in humans. Calcitonin decreases osteoclast activity, and decreases the formation of new osteoclasts, resulting in decreased resorption.

What drug accelerates resorption of bone?

Bisphosphonates. BPs are a class of drugs generally used in the treatment of bone disorders that are characterized by excessive osteoclastic bone resorption, such as osteoporosis, Paget’s disease, fibrous dysplasia, hypercalcemia of malignancy, and inflammation-related bone loss (12-15).

Which drugs inhibit the breakdown of bone?

Monoclonal antibodies such as denosumab (Prolia) inhibit osteoclast formation, decrease bone resorption, increase BMD, and reduce the risk of fracture. Another monoclonal antibody, romosozumab, binds sclerostin, a regulatory factor in bone metabolism.

Does vitamin D increase bone resorption?

Previous studies have shown that high doses of vitamin D did result in increased resorption of bone unless calcium was also supplemented. The active form of vitamin D called calcitriol increases the production of osteoclasts which enhance bone resorption.

Where is cathepsin found?

Cathepsins are typically found in acidic endocytic or lysosomal systems, but some cathepsins function above the optimal pH 5 level, namely cathepsin S, which is active at pH 6.5. Cathepsin D is usually most active at pH 4, but it has also been found that cathepsin D is active at higher pH levels up to pH 7.4.