What is diethyl azodicarboxylate used for?
It is used in the synthesis of various natural products and pharmaceuticals such as zidovudine, an AIDS drug; FdUMP, a potent antitumor agent; and procarbazine, a chemotherapy drug.
What is chemical formula represent?
A chemical formula tells you the specific elements present in a molecule represented by their symbols from the periodic table and the number of atoms of each present indicated by a subscript number following the symbol. So, H2O refers to two hydrogen atoms and one oxygen atom.
What is alcohol esterification?
Alcohols can combine with many kinds of acids to form esters. The reaction, called Fischer esterification, is characterized by the combining of an alcohol and an acid (with acid catalysis) to yield an ester plus water.
What do you mean by Mitsunobu reaction?
The organic reaction which is responsible for transforming primary and secondary alcohols into ethers by treating them with diethyl azodicarboxylate (DEAD) or diisopropyl azodicarboxylate (DIAD) and triphenylphosphine is known as Mitsunobu reaction.
What is didi-2-methoxyethyl azodicarboxylate (dmead)?
Di-2-methoxyethyl azodicarboxylate (DMEAD, 1) is our newly designed reagent that can be produced by a commercially viable process, and its advantage as a Mitsunobu reagent will be presented in this report ( Fig. 1 ). 18 Figure 1. DEAD and DIAD, the classic DAD analogues, and DMEAD ( 1 ), the new analogue. 2. Results and discussion 2.1.
How do you make dmead?
DMEAD was synthesized from hydrazine 2 by several oxidation methods, 19 and found to be a crystalline compound. A reaction with chlorine or sodium hypochlorite yielded DMEAD, but the purity obtained after the extraction was not sufficiently high to allow crystallization from the reaction mixture.
What is the best nucleophile for Mitsunobu reaction?
Sulfonamides, exhibiting pKa values of about 10, are excellent nucleophiles in the Mitsunobu reaction.2–5 Azide is also a superb nucleophile and may be administered in a variety of forms: hydrazoic acid, metal azide or diphenylphosphoryl azide (DPPA).2 Care must be taken, however]