What is Ductular reaction?

What is Ductular reaction?

Abstract. Ductular reaction (DR) is characterized by the proliferation of reactive bile ducts induced by liver injuries. DR is pathologically recognized as bile duct hyperplasia and is commonly observed in biliary disorders. It can also be identified in various liver disorders including nonalcoholic fatty liver disease …

Can a liver regenerate?

The liver has a unique capacity among organs to regenerate itself after damage. A liver can regrow to a normal size even after up to 90% of it has been removed.

What is Ductular proliferation?

Ductular proliferation is often used to describe the appearance of biliary epithelial cells in the portal tracts of diseased livers. The proliferating bile ductules are heterogeneous and are histologically classifiable into typical and atypical types[1].

What is Macrovesicular steatosis?

Steatosis in NAFLD is usually seen as macrovesicular steatosis (large droplet steatosis) in which a single, large vacuole of fat fills up the hepatocyte and displaces the nucleus to the periphery. Often macrovesicular steatosis can be present with both large and small droplets that may be seen to coalesce.

What causes periportal fibrosis?

Periportal fibrosis is a chronic disease, late-stage complication of schistosomiasis infection, discovered by Symmers. It is due to the presence of schistosomia eggs in portal venules, resulting in an embolization and an inflammatory reaction of the portal areas.

What is the difference between Microvesicular and Macrovesicular steatosis?

Microvesicular steatosis is characterized by the presence of numerous small vesicles of fat that do not displace the nucleus (Figures 1, 2). Macrovesicular steatosis is characterized by engorgement of the hepatocyte by a large fat globule that displaces the nucleus.

What is hepatocyte ballooning?

Background/aims: Hepatocyte “ballooning” is an often used but ill defined term in liver pathology to designate a special form of liver cell degeneration associated with cell swelling and enlargement found particularly in steatohepatitis.