What is enflurane used for?
Enflurane is a medication used in the induction and maintenance of general anesthetics. It is in the inhaled anesthetics class of drugs. This activity outlines the indications, action, and contraindications for enflurane as a valuable agent in the maintenance of general anesthetics.
Is enflurane still used?
Enflurane (2-chloro-1,1,2-trifluoroethyl difluoromethyl ether) is a halogenated ether. Developed by Ross Terrell in 1963, it was first used clinically in 1966. It was increasingly used for inhalational anesthesia during the 1970s and 1980s but is no longer in common use.
Where is the enflurane found?
About 72 hours after death, high amounts of enflurane were found in the brain, blood, and subcutaneous fat. Gas chromatographic studies revealed enflurane concentrations of 350 mg/l-1 in the brain, 130 mg/l-1 in the blood, and 100 mg/l-1 in the subcutaneous fat.
Is enflurane volatile?
Enflurane (Ethrane, 2-chloro-1,1,2-trifluoroethyldifluoromethyl ether) is a nonflammable halogenated hydrocarbon that exists as a clear, colorless, odorless to sweet, volatile liquid at ordinary temperature and pressure.
How do you pronounce enflurane?
Phonetic spelling of enflurane
- enflurane.
- en-flu-rane.
- en-flur-ane. Haley Runte.
How is enflurane administered?
Enflurane should ordinarily be administered in the concentration range of 0.5 to 1.0% to supplement other general anesthetics. See also the information on the effects of enflurane on uterine contraction contained in the CLINICAL PHARMACOLOGY section.
Is enflurane a gas?
Enflurane is a clear, colorless, stable liquid whose purity exceeds 99.9% (area percent by gas chromatography).
Is enflurane is a halogenated ether?
Enflurane, a halogenated methyl ethyl ether, is relatively pungent and high concentrations are associated with seizure-like EEG activity.
Enflurane (2-chloro-1,1,2,-trifluoroethyl-difluoromethyl ether) is a halogenated ether. Developed by Ross Terrell in 1963, it was first used clinically in 1966. It was increasingly used for inhalational anesthesia during the 1970s and 1980s but is no longer in common use.
Why is enflurane not recommended for people with epilepsy?
This is significantly higher than the metabolism of its structural isomer isoflurane . Enflurane also lowers the threshold for seizures, and should especially not be used on people with epilepsy. Like all potent inhalation anaesthetic agents it is a known trigger of malignant hyperthermia .
What is the medical definition of epilepsy?
Definition of epilepsy. : any of various disorders marked by abnormal electrical discharges in the brain and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.
Is enflurane a structural isomer of isoflurane?
Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature. Clinically, enflurane produces a dose-related depression of myocardial contractility with an associated decrease in myocardial oxygen consumption.