What is Ketek antibiotic used for?
Ketek (telithromycin) is an antibiotic used to treat bacterial infections in the lungs and sinuses.
Why was Ketek discontinued?
Ketek’s warning states that it should not be used in patients with myasthenia gravis, a disease that causes muscle weakness. Following this decision, Sanofi-Aventis withdrew the drug from active sales in the United States.
Is Ketek still on the market?
On March 11, 2016, the FDA announced that Sanofi Aventis discontinued the manufacturing of Ketek (telithromycin) 300 mg and 400 mg tablets. — The decision to discontinue Ketek was due to business reasons. — The last batch of Ketek expires in June 2016.
What drugs are Ketolides?
What Are Drug Names of Ketolides?
- Ketek.
- Solithera.
- Solithromycin.
- Telithromycin.
What is telithromycin used for?
Telithromycin is used to treat certain types of pneumonia (an infection of the lungs) that is caused by bacteria. Telithromycin is in a class of medications called ketolide antibiotics. It works by killing bacteria. Antibiotics such as telithromycin not work for colds, flu, or other viral infections.
What is the risk of telithromycin associated liver failure?
Mild and anicteric cases of liver injury attributed to telithromycin have been reported, but some cases are very severe and associated with rapid development of hepatic failure with ascites and hepatic encephalopathy. Eosinophilia and rash can occur, but are not common.
What drug class is Ketek?
KETEK tablets contain telithromycin, a semisynthetic antibacterial in the ketolide class for oral administration.
Is telithromycin a macrolide?
The ketolides are a new subclass of macrolides, and telithromycin is the first of these agents to be approved. Modifications to the basic macrolide structure result in enhanced activity against penicillin- and erythromycin resistant respiratory pathogens.
How do Ketolides work?
Ketolides have a mechanism of action very similar to erythromycin A from which they have been derived. They potently inhibit protein synthesis by interacting close to the peptidyl transferase site of the bacterial 50S ribosomal subunit. Ketolides bind to ribosomes with higher affinity than macrolides.
How is telithromycin excreted?
The systemically available telithromycin is eliminated by multiple pathways as follows: 7% of the dose is excreted unchanged in feces by biliary and/or intestinal secretion; 13% of the dose is excreted unchanged in urine by renal excretion; and 37% of the dose is metabolized by the liver.
What is Ketek used to treat?
What is Ketek? Ketek (telithromycin) is an antibiotic that fights bacteria. Ketek is used to treat mild to moderate pneumonia caused by certain types of bacteria. Ketek may also be used for purposes not listed in this medication guide.
Is Ketek the first antimicrobial drug approved by FDA?
Three years ago, the Food and Drug Administration (FDA) approved the drug Ketek (telithromycin), lauding it as the first of a new class of antimicrobial agents that circumvent antibiotic resistance.
What is telithromycin Ketek used to treat?
Ketek (telithromycin) is an antibiotic that fights bacteria. Ketek is used to treat mild to moderate pneumonia caused by certain types of bacteria. Ketek may also be used for purposes not listed in this medication guide.
What is the indication of keetoketek?
KETEK is indicated for the treatment of community- acquired pneumonia (of mild to moderate severity) due to Streptococcus pneumoniae, (including multi-drug resistant S. pneumoniae [MDRSP 1 ]), Haemophilus influenzae, Moraxella catarrhalis, Chlamydophila pneumoniae, or Mycoplasma pneumoniae, for patients 18 years or older.