What is menadione sodium bisulfite used for?
Menadione or its sodium bisulfite derivatives and other vitamin K preparations are used in the treatment of the hemorrhagic diathesis of obstructive jaundice, the hemorrhagic states associated with primary hepatic disease, the hemorrhagic states which accompany certain intestinal disease such as ulcerative colitis.
What is menadione sodium bisulfite?
Menadione Sodium Bisulfite acts as a vitamin K analogue. Vitamin K is an essential fat soluble vitamin that is important in maintaining normal coagulation, serving as a cofactor in the synthesis of several clotting factors, such as Factor II, VII, IX, X in the liver, and anticoagulant proteins.
What is the function of menadione?
Menadione (vitamin K3) is involved as a cofactor in the posttranslational gamma-carboxylation of glutamic acid residues of certain proteins in the body.
Is menadione a form of vitamin K?
Vitamin K is the name of a family of compounds with a similar structure. Vitamin K3, also known as menadione, is a synthetic or artificially produced form of vitamin K.
Where does K1 come from?
Vitamin K1 is obtained from leafy greens and some other vegetables. Vitamin K2 is a group of compounds largely obtained from meats, cheeses, and eggs, and synthesized by bacteria. Vitamin K1 is the main form of vitamin K supplement available in the U.S.
Where do you inject vitamin K?
This medication is given by injection under the skin or into a muscle or vein as directed by your doctor. If this medication is given into a vein, it should be injected very slowly (no more than 1 milligram per minute) to reduce the risk of serious side effects. (See also Warning section.)
What is chemical name of menadione?
Menadione
| PubChem CID | 4055 |
|---|---|
| Structure | Find Similar Structures |
| Chemical Safety | Laboratory Chemical Safety Summary (LCSS) Datasheet |
| Molecular Formula | C11H8O2 |
| Synonyms | menadione 58-27-5 Vitamin K3 2-Methyl-1,4-naphthoquinone 2-methylnaphthalene-1,4-dione More… |
What is formulation of menadione?
Menadione is a natural organic compound with the formula C6H4(CO)2C2H(CH3). It is an analog of 1,4-naphthoquinone with a methyl group in the 2-position. It is sometimes called vitamin K3. Use is allowed as a nutritional supplement in animal feed because of its vitamin K activity.
How does menadione generate superoxide?
A number of earlier studies have suggested that menadione (2-methyl-1,4-naphthoquinone; vitamin K3) is a superoxide generator, which induces the production of superoxide inside the cells via one-electron transfer reactions (Iyanagi and Yamazaki, 1970; Thor et al., 1982; White and Clark, 1988).
What’s the difference between vitamin K2 and vitamin K?
Vitamin K1 is primarily found in leafy green vegetables, while K2 is most abundant in fermented foods and some animal products. Vitamin K2 may be absorbed better by the body and some forms may stay in the blood longer than vitamin K1. These two things may cause K1 and K2 to have different effects on your health.
Is vitamin K and K1 the same?
Vitamin K1 is the predominant form of vitamin K present in the diet [6,7]. K1 is predominantly found in green vegetables and plant chlorophylls, whereas K2 menaquinones are synthesized by bacteria [8] and are primarily found in food where bacteria are part of the production process [5,9].
Can vitamin K be given intramuscular?
Vitamin K is available in injectable and oral formulations. According to the product’s labeling, vitamin K solution for injection can be administered intravenously, intramuscularly, and subcutaneously with higher preference for the subcutaneous route due to the risk of anaphylaxis with the intravenous route.
Menadione sodium bisulfite is a water-soluble form of menadione, which belongs to the Vitamin K class of compounds. These are necessary for the biosynthesis of prothrombin and other blood clotting factors. Menadione is a prothrombogenic compound and is used as a model quinone in cell culture and in vivo investigations.
Is menadione sodium bisulfite safe for cats?
Menadione Sodium Bisulfite has NEVER been proven safe for use in cat foods or dog foods.
Is vitamin K3 the same as menadione?
Menadione, also known as Vitamin K3, is a synthetic version of Vitamin K. Commonly in the form of Menadione Sodium Bisulfate (MSB) and Menadione Nicotinamide Bisulfite (MNB) used widely as feed additives in animal and poultry such as in dog and cat food.
Can you use menadione in dog food?
Menadione or Menadione sodium bisulfite complex has a GRAS status for use in poultry feed at 2 to 4 g per ton of feed (Federal Register 55:50777, December 10, 1990). States and FDA have given low regulatory priority for use of the above vitamin as source of vitamin K in other species’ feeds including pet food.