What is platensimycin (12)?
Platensimycin (12 ), an ent -kaurene diterpenoid with the degraded A ring, was first discovered by the Merck research group by employing an antisense differential sensitivity screening strategy. The first total synthesis of PTM was reported by Nicolaou et al. [40] in the same year when platensimycin was discovered.
How is platensimycin isolated from Streptomyces platensis?
Platensimycin was first isolated from a strain of Streptomyces platensis by the Merck group [1] by using two-plate system where control organisms were compared to cells expressing fabF antisense RNA. This method uses the combination of target-based whole-cell and biochemical assays.
What is plastiplatensimycin 71?
Platensimycin 71 is a novel broad-spectrum antibiotic that was isolated from Streptomyces platensis by scientists from Merck in 2006 ( 2006JACS11916 ). As a result of its biological properties and challenging structure, platensimycin has been the focus of some intense synthetic activity ( 2007ACIE3942, 2007OL4921 ).
What does platensimycin do to Gram positive bacteria?
Platensimycin has shown good activity against a panel of Gram-positive bacteria, including various resistant strains. Platensimycin works by inhibiting beta-ketoacyl synthases I/II (FabF/B), which are involved in the production of fatty acids required for bacterial cell membranes.