What is Pt complex?
Cisplatin [Pt(NH3)2(Cl)2] is a platinum complex and a major anticancer drug, but it has a few problems such as nephrotoxicity and drug resistance. As palladium is a congener of platinum, its character is similar to that of platinum. Thus, palladium complexes are expected to provide alternatives to cisplatin.
What are platinum complexes?
Platinum complexes like cisplatin and carboplatin (Fig. 13.7) exert their antitumor effects by forming DNA adducts and subsequent inhibition of DNA replication and transcription. They have an important role in the treatment of several solid tumors.
Which platinum complex is used in cancer chemotherapy?
Among many chemotherapy drugs that are widely used for cancer, Cisplatin is one of the most compelling ones. It was the first FDA-approved platinum compound for cancer treatment in 1978 (Kelland, 2007).
Which complex has medicinal value?
Many coordination complexes have been used in medicine containing metals such as platinum (cisplatin as anticancer chemotherapy drug), gold (as auranofin used for rheumatoid arthritis), technetium and rhenium (as radiopharmaceuticals used in imaging and radiotherapy), ruthenium (as anticancer drug), gadolinium, cobalt.
Which of the following coordination complex ion is used for the treatment of tumors?
Since the discovery of cisplatin, coordination complexes have been widely used in cancer therapy.
Who makes oxaliplatin?
The sanofi-aventis Group announced today that it has received marketing approval from the United States Food and Drug Administration for a new aqueous solution formulation of ELOXATIN™ (oxaliplatin injection).
Which compound is used in cancer therapy?
Platinum drugs, such as cisplatin, carboplatin and oxaliplatin, are the mainstay of the metal-based compounds in the treatment of cancer, but the delay in the therapeutic accomplishment of other metal-based compounds hampered the progress of research in this field.
Why is platinum in chemotherapy?
The platinum compounds are largely used in the treatment of lung, breast, ovarian, and colon cancers. The chemotherapeutic mechanism of platinum compounds is typical of DNA-binding alkylating agents. If the DNA damage exceeds the ability of the cell to repair, the cell undergoes apoptotic cell death.
How does complexation affect the drug action?
Drug molecules can form complexes with other small molecules or with macromolecules such as proteins. Once complexation occurs, the physical and chemical properties of the complexing species are altered. In some instances, complexation also can lead to poor solubility or decreased absorption of drugs in the body.
What is Zeise’s Salt draw its structure?
Zeise’s salt, potassium trichloro(ethylene)platinate(II), is the chemical compound with the formula K[PtCl3(C2H4)]·H2O….Zeise’s salt.
| Names | |
|---|---|
| Chemical formula | C2H6Cl3KOPt |
| Molar mass | 386.60 g·mol−1 |
| Appearance | Yellow to orange crystals |
| Melting point | 220 °C |
Which complex is useful in inhibiting the growth of tumors?
Selective Ru(II)/lawsone complexes inhibiting tumor cell growth by apoptosis.
What is the difference between PTSD and complex PTSD?
“PTSD is generally related to a single event or specific events, whereas complex PTSD is related to a series of events or one prolonged event,” Walden told The Mighty. “This can mean the difference between a traumatic car accident one had in childhood and childhood itself.”
What are the 17 symptoms of PTSD?
Re-Experiencing. Frequent upsetting thoughts or memories of a traumatic event. Being physically responsive,such as increased heart rate or sweating,when reminded of the event.
What are the symptoms of complex PTSD/Complex trauma?
Most people who experience PTSD because of a traumatic event may have difficulty coping and may experience symptoms like insomnia, flashbacks, low self-esteem and unpleasant emotions . In the U.S. alone, around 3.5% of the population or approximately 8 million Americans, suffer from this mental health condition in a given year.