What is responsible for bone deposition?
Osteoblasts are the cells that are responsible for bone deposition while osteoclasts are the cells that are responsible for bone resorption.
What is the process of bone resorption?
The process of resorption (remodeling) involves the removal of hard bone tissue by osteoclasts followed by the laying down of new bone cells by osteoblasts. Resorption releases calcium and repairs micro-damage to bones from normal wears and tears.
What is bone Remodelling process?
Bone remodeling (or bone metabolism) is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation). In the first year of life, almost 100% of the skeleton is replaced.
What is accomplished by bone remodeling?
Bone remodeling is a process in which bone resorption ensues, providing calcium, phosphorus, or carbonate and bicarbonate salts to the extracellular medium, a pathway that is coupled to bone synthesis, so that total bone mass is preserved.
What is the role of calcitonin in bone deposition?
Calcitonin: A hormone produced by the thyroid gland that lowers the levels of calcium and phosphate in the blood and promotes the formation of bone. Calcitonin inhibits bone removal by the osteoclasts and at the same time promotes bone formation by the osteoblasts. …
What causes bone formation?
The growth hormone/IGF-1 system stimulates both the bone-resorbing and bone-forming cells, but the dominant effect is on bone formation, thus resulting in an increase in bone mass. Thyroid hormones increase the energy production of all body cells, including bone cells.
What is a process of a bone?
bone formation, also called ossification, process by which new bone is produced. Soon after the osteoid is laid down, inorganic salts are deposited in it to form the hardened material recognized as mineralized bone. The cartilage cells die out and are replaced by osteoblasts clustered in ossification centres.
What is the bone remodeling process?
Bone remodeling involves the removal of mineralized bone by osteoclasts followed by the formation of bone matrix through the osteoblasts that subsequently become mineralized. The regulation of bone remodeling is both systemic and local.
What is the correct sequence of steps in bone repair quizlet?
Steps in the repair of a bone fracture include (1) bone deposition by osteoblasts, (2) bone and debris removal by osteoclasts, (3) hematoma, and (4) formation of a fibrocartilage callus.
What two factors are responsible for bone remodeling?
Introduction. Bone remodeling is the result of two opposite activities, the production of new bone matrix by osteoblasts and the destruction of old bone by osteoclasts.
What is the process of bone deposition and resorption?
Bone Deposition and Resorption. The calcium phosphate in these hydroxyap-atite crystals is derived from the blood by the action of bone-forming cells, or osteoblasts. The osteoblasts secrete an organic matrix composed largely of collagen protein, which becomes hardened by deposits of hydroxyapatite. This process is called bone deposition.
How does the MicroElectrical effect contribute to bone deposition?
This microelectrical effect is part of a complex cascade of biochemical events that contribute to bone deposition. In response to external stimuli: Calcitonin is secreted and activates osteoblasts. Osteoblasts secrete osteoid (a composite of collagen, chondroitin sulfate, and osteocalcin).
How do osteoclasts de-mineralize bone?
During this first step, many preosteoclasts mature into osteoclasts, which are able to de-mineralize the bone. Once activated, the osteoclasts can secrete various enzymes including collagenases that are capable of digesting the mineralized bone and its collagen.
How do you dissolve calcium phosphate in bone?
The dissolution of calcium phosphate is accomplished by transport of H+ by a H+-ATPase pump in the ruffled membrane, thereby acidifying the bone matrix (to a pH of about 4.5) immediately adjacent to the osteoclast. A channel for Cl- allows Cl-to follow the H+, preserving electrical neutrality.