What is the blood gas partition coefficient of halothane?
Inhalational anaesthetics
| Partition coefficients at 37 °C | ||
|---|---|---|
| Anesthetic | MAC (%) | Blood/gas |
| Nitrous oxide | 105 | 0.47 |
| Halothane | 0.74 | 2.4 |
| Isoflurane | 1.15 | 1.4 |
What is the blood gas partition coefficient of sevoflurane?
We found a blood/gas partition coefficient of 1.45 ± 0.12 (mean ± SD) for isoflurane, 0.74 ± 0.06 for sevoflurane, and 0.57 ± 0.04 for desflurane.
How the blood gas partition coefficient of an inhalation anesthetic influences its speed of onset of anesthesia and its recovery time?
A higher blood–gas partition coefficient (higher solubility) leads to greater uptake by the pulmonary circulation, but a slower increase in alveolar partial pressure of the agent (FA/Fi ratio) and therefore more prolonged induction and recovery from anaesthesia.
What does a high blood gas partition coefficient mean?
A higher blood-to-gas coefficient correlates with a greater concentration of anesthetic in blood (i.e., a higher solubility). Therefore a greater amount of anesthetic is taken into the blood, which acts as a reservoir for the agent, reducing the alveolar concentration and thus slowing the rate of induction.
Why are Macs Higher kids?
Children have a higher tolerance to the dysrhythmic effects of epinephrine during general anesthesia with volatile agents. In general, children have higher drug requirements (mg/kg) because they have a greater volume of distribution (more fat, more body water).
What does a low blood gas partition coefficient mean?
The low blood gas partition coefficient (1.4 at 37°C) means that there is a low solubility of isoflurane in blood and tissues, which leads to a rapid induction and recovery due to less retention following tissue distribution.
What does a high blood gas coefficient mean?
Therefore, if the gas is in equilibrium the concentration in blood will be 1.7 times higher than the concentration in the alveoli. Thus, it makes sense that a gas with a higher blood gas coefficient will require higher uptake of gas into the blood and induction will be slower.
What is the blood/gas coefficient of halothane?
The blood/gas coefficient is 2.5 at 37° C, and the olive oil/water coefficient is 220 at 37° C. Vapor concentrations within anesthetic range are nonirritating and have a pleasant odor. Halothane is nonflammable, and its vapors mixed with oxygen in proportions from 0.5 to 50% (v/v) are not explosive.
What are the analgesic properties of halothane?
Anesthetic Properties of Halothane : It is potent anesthetic (MAC = 0.74). Blood gas coefficient of 2.4 makes it agent with moderate induction and recovery time. Not a good analgesic. Muscle relaxation is moderate.
Is halothane still available in the United States?
It is no longer commercially available in the United States. Halothane also contributes to ozone depletion. It is a potent anesthetic with a MAC of 0.74%. Its blood/gas partition coefficient of 2.4 makes it an agent with moderate induction and recovery time. It is not a good analgesic and its muscle relaxation effect is moderate.
Is halothane a nonirritant or irritant?
Nonirritant, so induction is very smooth. Boiling point of Halothane is 50°C. Halothane has highest fat/blood coefficient (51) can get deposited in adipose tissue after prolonged exposure. It is potent anesthetic (MAC = 0.74).