What is the concentration of dexmedetomidine?
The effective sedative concentration of dexmedetomidine was thought to be between 0.2 and 3.2 ng/ml in previous studies.
How do you dilute dexmedetomidine?
Dexmedetomidine injection concentrate (100 mcg/mL) must be diluted in 0.9% sodium chloride solution to achieve the required concentration (4 mcg/mL) prior to administration. Add 2 mL (200 mcg) of dexmedetomidine to 48 mL of 0.9% sodium chloride for a total volume of 50 mL (4 mcg/mL).
How do you titrate dexmedetomidine?
Start at 0.2 – 0.4 mcg/kg/hour and titrate to 0.1 – 0.2 mcg/kg/hour every 30 minutes to a maximum rate of 1.1 mcg/kg/hour. Adjust rate to achieve the targeted level of sedation.
How is dexmedetomidine metabolized?
Dexmedetomidine is metabolized by the liver, largely by glucuronidation (34%) as well as by oxidation via CYP2A6 and other Cytochrome P450 enzymes. As such, it should be used with caution in people with liver disease. The majority of metabolized dexmedetomidine is excreted in the urine (~95%).
Is dexmedetomidine a lipid soluble?
Dexmedetomidine, which is also highly lipid soluble (Log [octanol/water partition coefficient]: 2.8), produces severe transient hypertension at high doses mediated by alpha-2 adrenoceptor stimulation in vascular smooth muscles.
How do you make dexmedetomidine?
To prepare the infusion, withdraw 2 mL of Precedex Injection Concentrate, and add to 48 mL of 0.9% sodium chloride injection to a total of 50 mL. Shake gently to mix well.
How do you take dexmedetomidine?
loading dose of 1 mcg/kg over 10-20 minutes followed by a maintenance infusion in the range of 0.2- 0.7mcg/kg/hr. The rate of infusion can be increased in increments of 0.1mcg/kg/hr or higher. IM injection (2.5 mcg/kg) of dexmedetomidine has been used for premedication.
Is dexmedetomidine compatible with dextrose?
Precedex has been shown to be compatible when administered with the following intravenous fluids: 0.9% sodium chloride in water. 5% dextrose in water.
How do you give dexmedetomidine?
What is the concentration of butorphanol?
Butorphanol is administered at 0.4 mg/kg body weight by deep intramuscular injection in the gluteal region 5-20 min prior to procedures.
What is dexmedetomidine used for?
Dexmedetomidine is used as an adjuvant for premedication, especially in patients susceptible to preoperative and perioperative stress because of its sedative, anxiolytic, analgesic, sympatholytic, and stable hemodynamic profile.
How much dexmedetomidine is in a sodium chloride injection?
Dexmedetomidine HCl in 0.9% sodium chloride injection, 400 mcg dexmedetomidine/100 mL (4 mcg/mL) dexmedetomidine in a glass bottle. Ready to use. None. Dexmedetomidine HCl in 0.9% sodium chloride injection should be administered only by persons skilled in the management of patients in the intensive care or operating room setting.
How do you dilute dexdexmedetomidine?
Dexmedetomidine injection must be diluted with 0.9% sodium chloride injection to achieve required concentration (4 mcg/mL) prior to administration. Preparation of solutions is the same, whether for the loading dose or maintenance infusion.
How long does dexmedetomidine stay stable in the body?
Dexmedetomidine diluted to 4 μg/mL in 0.9% sodium chloride injection was stable for at least 48 hours at 20-25 °C and 14 days at 5 °C when stored in polypropylene syringes. Dexmedetomidine diluted to 4 μg/mL in 0.9% sodium chloride injection was stable for at least 48 hours at 20-25 °C and 14 days at 5 °C when stored in polypropylene syringes.
What drugs are compatible with dexmedetomidine HCl?
Dexmedetomidine HCl in 0.9% sodium chloride injection has been shown to be incompatible when administered with the following drugs: amphotericin B, diazepam. Dexmedetomidine HCl in 0.9% sodium chloride injection has been shown to be compatible when administered with the following intravenous fluids: