What is the function of CREB?
CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element.
What is CREB neuroscience?
The cAMP-response element binding protein (CREB) is an intracellular protein that regulates the expression of genes that are important in dopaminergic neurons. Dopamine affects the phosphorylation of CREB via G protein-coupled receptors.
What is the size of CREB?
75 kDa
Size-exclusion chromatography suggests CREB is aggregated Unexpectedly, we found that CREB, a 75 kDa dimer in solution, eluted from the HiLoad Superdex 200 column in two contiguous high molecular weight peaks.
What genes are activated by CREB?
Genes whose transcription is regulated by CREB include: c-fos, BDNF, tyrosine hydroxylase, numerous neuropeptides (such as somatostatin, enkephalin, VGF, corticotropin-releasing hormone), and genes involved in the mammalian circadian clock (PER1, PER2).
Is CREB a coactivator?
The transcription factor CREB binds to a DNA element known as the cAMP-regulated enhancer (CRE). Consistent with its role as a coactivator, CBP augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes.
What is CREB memory?
From Wikipedia, the free encyclopedia. The cellular transcription factor CREB (cAMP response element-binding protein) helps learning and the stabilization and retrieval of fear-based, long-term memories. This is done mainly through its expression in the hippocampus and the amygdala.
What is CREB psychology?
CREB (cAMP response element binding) is a protein that is a transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE) and thereby increases or decreases the transcription, and thus the expression, of certain genes. CREB proteins are expressed in many animals, including humans.
What does CREB 2 do?
CAMP response element-binding protein 2(CREB2) is also known as Activating Transcription Factor 2 (ATF2). CREB2 is a CREB repressor, which means it inhibits long-term memory formation. CAMP response element-binding (CREB) proteins are transcription factors which bind to sequences of DNA called cAMP response elements.
What best describes the mechanism by which the coactivator CREB binding protein CBP activates transcription?
The transcriptional coactivator CREB binding protein (CBP) possesses intrinsic histone acetyltransferase (HAT) activity that is important for gene regulation. CBP binds to and cooperates with numerous nuclear factors to stimulate transcription, but it is unclear if these factors modulate CBP HAT activity.
How does CREB mediated gene expression regulation generally work?
It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. CREB proteins are expressed in many animals, including humans.
How does CREB affect memory?
CREB’s affects memory consolidation through its regulation of adult hippocampal neurogenesis (AHN), which mainly occurs in the hippocampal subgranular zone (SGZ) of the dentate gyrus (DG). This mechanism provides a novel perspective on memory consolidation within the adult hippocampus.