What is the pathophysiology of Brugada syndrome?
Brugada syndrome (BrS) has originally been described as an autosomal-dominant inherited arrhythmic disorder characterized by ST elevation with successive negative T wave in the right precordial leads without structural cardiac abnormalities. 1, 2 Patients are at risk for sudden cardiac death (SCD) due to ventricular fibrillation (VF).
Which countries have the highest prevalence of Brugada ECG?
Overall, type 1 and 2 Brugada ECG is more frequently observed in Asia than in Europe or the United States.
What is the history of coved-type ST-segment elevation on 12-lead ECG?
Since 1953, the ECG pattern similar to coved-type ST-segment elevation was reported as a normal variant in the healthy population or related to VF with structural abnormality, 3 – 5 but as a distinct disease entity, Brugada and Brugada 1 were the first to report 8 patients with VF, right bundle branch block, and ST-segment elevation on 12-lead ECG.
What are the diagnostic criteria for BRS?
The diagnostic criteria of BrS consist of 2 parts: (1) detection of the typical ECG abnormality and (2) clinical characteristics. 49 Coved-type ST-segment elevation and negative T wave in the right precordial leads ( Figure 3) with or without a drug challenge test in the 12-lead ECG is the hallmark of diagnosis.
Introduction Brugada syndrome is a genetic disease that is characterized by sudden death associated with abnormal electrocardiogram disorder. One of several ECG patterns characterized by are incomplete right bundle-branch block and ST- segment elevations in the anterior precordial leads (V1-V3) without ischemia.
What causes syncope and sudden death in Brugada syndrome?
Introduction The cause of syncope and sudden death in Brugada syndrome are caused by fast polymorphic ventricular tachycardias or ventricular fibrillation. These arrhythmias appear with no warning. According to clinical reports, sudden death in people with Brugada syndrome most often happens during sleep.
Do late potentials on electrocardiogram predict arrhythmic events in Brugada syndrome?
• In a prospective study of 43 patients with Brugada syndrome, the presence of late potentials on signal- averaged electrocardiogram was significantly predictive of arrhythmic events.