What is the role of dolichol phosphate?
Functions. Dolichols play a role in the co-translational modification of proteins known as N-glycosylation in the form of dolichol phosphate. Dolichols function as a membrane anchor for the formation of the oligosaccharide Glc3-Man9-GlcNAc2 (where Glc is glucose, Man is mannose, and GlcNAc is N-acetylglucosamine).
Is Dolichol a lipid?
Dolichols are the longest lipids in humans, most commonly consisting of 95 carbons (19 isoprenyl units). Originating from the terminal phosphate of Dol-P, a 14-sugar oligosaccharide unit with a pyrophosphate linkage is assembled in a stepwise manner (Figure 1).
Which reaction involves the use of dolichol?
This compound is involved in several glycosylation reactions: N-glycosylation, glycosylphosphatidylinositol-anchor biosynthesis, and C- and O-mannosylation.
What is dolichol pyrophosphate?
Dolichyl pyrophosphate serves as a carrier in this biosynthetic pathway. In this review, we discuss the function of the lipid carrier dolichol in oligosaccharide assembly and give an overview of the biosynthesis of the different sugar donors required for the building of the oligosaccharide.
Is dolichol a terpene?
Dolichol phosphate belongs to the class of organic compounds known as sesquiterpenoids. These are terpenes with three consecutive isoprene units.
Which reaction involves the use of Dolichol?
Is Dolichol a terpene?
What is the pathway for the synthesis of dolichol phosphate?
The pathway for de novo synthesis of dolichol phosphate is the same as for cholesterol until production of farnesyl pyrophosphate (Chapter 19). Two salvage pathways provide for the reutilization of dolichol and dolichol pyrophosphate once transfer of oligosaccharide from the dolichol to glycoprotein has occurred.
What is the structure and function of dolichol?
They are related in structure and function to undecaprenyl phosphate, a prokaryotic polyisoprenol used in the synthesis of peptidoglycan (see below). Dolichols contain 65–110 carbons arranged as 13–22 isoprene units, two in the trans configuration, the remainder in the cis configuration.
What is the role of diphosphates in glycoprotein biochemistry?
The discovery that dolichol phosphates and pyrophosphates (diphosphates) are carriers for oligosaccharides in eukaryotic cells initiated the modern era of glycoprotein biochemistry. These lipid-linked oligosaccharides are precursors for the carbohydrate side chains of the asparagine-linked glycoproteins.
What is the chemical name of the compound named dolichol phosphate?
Dolichol phosphate is a polyisoprenoid compound synthesized from the isoprenoid intermediates of the de novo cholesterol biosynthesis pathway.