What receptor is responsible for weight gain?
For the most part, high H1-histamine receptor affinities were associated with drugs that cause weight gain, whereas drugs that induce little or no weight gain had low H1-histamine receptor affinities.
What is serotonin 2C antagonist?
Abstract. Antagonists of the serotonin (5-hydroxytryptamine; 5-HT) type 2C receptor (5-HT2CR) are being considered as potential pharmacotherapeutics for various affective disorders, but evidence suggests that these compounds enhance the effects of cocaine and related psychostimulants in rodents.
Why do H1 antagonists cause weight gain?
During short-term treatment, hypothalamic H1 receptor antagonism by SGAs may activate the AMPK-carnitine palmitoyltransferase 1 signaling to rapidly increase caloric intake and result in weight gain.
Which antipsychotic causes most weight gain?
Olanzapine and zotepine caused significantly more weight gain than most other antipsychotics. Another head-to-head meta-analysis reported that olanzapine and clozapine cause the highest amount of weight gain, while quetiapine, risperidone and sertindole caused intermediate amounts.
Is Vortioxetine an SSRI?
Vortioxetine is an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator. This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.
What is an agonist what is an antagonist?
An agonist is a drug that binds to the receptor, producing a similar response to the intended chemical and receptor. Whereas an antagonist is a drug that binds to the receptor either on the primary site, or on another site, which all together stops the receptor from producing a response.
What happens when serotonin receptors are blocked?
Serotonin syndrome occurs when serotonin accumulates to high levels in the body, as can happen when medicines block the chemical from entering cells. The syndrome is characterised by: altered mental state, e.g. confusion, agitation, restlessness and excitement.
Which serotonin receptor suppresses appetite?
The pivotal role of 5-HT in the control of appetite was formally proposed nearly 30 years ago. In particular endogenous hypothalamic 5-HT has been implicated in the processes of within meal satiation and the end state of post meal satiety.
What are examples of agonist and antagonist drugs?
Examples of full agonists are heroin, oxycodone, methadone, hydrocodone, morphine, opium and others. An antagonist is a drug that blocks opioids by attaching to the opioid receptors without activating them. Antagonists cause no opioid effect and block full agonist opioids. Examples are naltrexone and naloxone.
What are the examples of serotonin antagonists?
Serotonin Antagonists boost serotonin by blocking its reuptake at nerve synapses, much like the SSRIs. Examples of Serotonin Antagonists are: trazodone (Desyrel) and nefazodone (Serzone). They are useful in case of persons suffering from anxiety and depression.
What is the agonist and antagonist?
In pharmacology the term agonist-antagonist or mixed agonist/antagonist is used to refer to a drug which under some conditions behaves as an agonist (a substance that fully activates the receptor that it binds to) while under other conditions, behaves as an antagonist (a substance that binds to a receptor but does not activate and can block the
What are opiate agonist and antagonist drugs?
The Difference between Opiate Agonist and Antagonist Drugs. Opiate antagonist drugs are those that actually attach to opioid receptors in the body, but don’t activate them. They block the effects of opioid agonists without causing a high. Some antagonists actually do produce a weak effect while others produce no effect at all.