What type of cells are melanocytes?

What type of cells are melanocytes?

Melanocytes. Melanocytes are dendritic, pigment-producing cells located in the basal cell layer (Figs 2.4, 2.5). They protect the skin from ultraviolet radiation. Individuals with little or no pigment develop marked sun damage and numerous skin cancers.

In which cell layer do you find melanocytes?

basal cell layer
The basal cell layer contains cells called melanocytes.

Do melanocytes have a cell membrane?

As melanosomes in normal human melanocytes are distributed individually in the cytosol with no surrounding membranes (Figure 1h), this indicates that melanosomes themselves are not a type of exosome enclosed by intracellular multivesicular bodies.

What are Langerhans cells?

Langerhans cells (LC) are a unique population of tissue-resident macrophages that form a network of cells across the epidermis of the skin, but which have the ability to migrate from the epidermis to draining lymph nodes (LN). Their location at the skin barrier suggests a key role as immune sentinels.

What tissues have melanocytes?

Melanocytes are melanin-producing neural crest-derived cells located in the bottom layer (the stratum basale) of the skin’s epidermis, the middle layer of the eye (the uvea), the inner ear, vaginal epithelium, meninges, bones, and heart.

What are Langerhans cells function?

Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels. These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in which they encounter foreign substances.

Are melanocytes found in the epidermis?

In the human skin, melanocytes are present in the epidermis and hair follicles. The basic features of these cells are the ability to melanin production and the origin from neural crest cells.

Which stratum contains stem cells?

The innermost basal layer, stratum basale (SB), consists in undifferentiated keratinocytes, stem cells, melanocytes, and Merkel cells. On top of this layer resides the spinous layer, stratum spinosum (SS).

Are Langerhans cells macrophages?

Are Langerhans cells macrophages or dendritic cells?

Based on their developmental origin, LCs are a specialized epidermal tissue macrophage subset that is seeded into skin prenatally. Once thought to be prototypic representatives of the dendritic cell (DC) lineage, they are now considered to be a specialized subset of tissue-resident macrophages.