What is povidone K90?
Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights.
Is PVP K90 safe?
Review, 1101 17th Street, NW, Suite 310, Washington, DC 20036, USA. available data, it was concluded that PVP is safe as used in cosmetics. a molecular weight (MW) of 111.1; the molecular weight of the poly- mer can range from 10,000 to 700,000 (IARC 1979).
What is Plasdone k29 32?
Plasdone™ k-29/32 polymer is a stable, water-soluble polyvinylpyrrolidone that meets U.S., European and Japanese pharmacopoeia specifications for Povidone. The polymer can be effectively used to bind and remove stains through hydrogen bonding with chemical compounds.
Is povidone soluble in acetone?
The solubility in acetone is 1–2%. The dissolution behaviour and dissolution rate are typical for a polymer. It is recommended to add the powder slowly and in small portions to the solvent with vigorous stirring to ensure that it disperses and dissolves rapidly without forming lumps.
Is polyvinylpyrrolidone bad for hair?
PVP/ VA copolymer PVP/VA copolymer is the ingredient found in most hair care products that provides the “hold factor.” (Think: hairsprays.) It is another toxic chemical derived from petroleum that’s known to cause irritation to the scalp, as well as respiratory issues in some people.
What is the difference between povidone K30 and K90?
-The medium molecular weights such as PVP K30 are preferred where viscosity is critical in applications, for example, spray. -The higher molecular weight products such as PVP K90 are better choice where high viscosity are needed in applications.
Is povidone organic or inorganic?
6 Polyvinylpyrrolidone (povidone) Polyvinylpyrrolidone (PVP) is a non-ionic synthetic polymer composed of repeating 1-vinyl-2-pyrrolidone monomers. Soluble forms of PVP, also known as povidone, are used extensively in the pharmaceutical industry largely as a binder in tablet manufacturing.
What is povidone made of?
Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.
Is polyvinylpyrrolidone safe for skin?
Conclusion. In the 1998 safety assessment of polyvinylpyrrolidone (PVP), the Cosmetic Ingredient Review (CIR) Expert Panel (Panel) concluded that this ingredient was safe as used in cosmetic products.
What is plasdone™ k-29/32 polymer?
Plasdone™ K-29/32 polymer is a stable, water-soluble polyvinylpyrrolidone that meets U.S., European and Japanese pharmacopoeia specifications for Povidone. Plasdone K-29/32 polymer forms complexes with catechins, just as it does with many other compounds that cause discoloration of teeth.
What is plasdone C grade povidone?
Plasdone™ povidone C grades are supplied with low pyrogen levels and can increase solubilization or inhibit crystallization in parenteral dosage forms. The regulatory compliance information for all Ashland products varies by product family and grade.
What is the properties of PvP in K90 polymer?
PVP (Polyvinylpyrrolidone) K-90 polymer is a hygroscopic, amorphous polymer. It is a linear nonionic polymer that is soluble in water and organic solvents and is pH stable. It forms hard glossy transparent films and have adhesive and cohesive properties.
What is polyplasdone xl-10 crospovidone?
Polyplasdone XL-10 crospovidone has been shown to increase the dissolution rate of poorly soluble drugs compared with other superdisintegrants. And, as Polyplasdone polymers are nonionic in nature, they will not interact with cationic drug actives to retard drug release.