What is peyona?
Peyona contains the active substance caffeine citrate, which is a stimulant of the central nervous system, belonging to a group of medicines called methylxanthines. Peyona is used in the treatment of interrupted breathing in premature babies (primary apnoea of premature newborns).
Why is caffeine used in neonates?
Caffeine is routinely administered to extremely preterm neonates as a respiratory stimulant to prevent or treat apnea of prematurity, or prolonged pauses in breathing in preterm babies.
How much caffeine in caffeine citrate?
Each mL contains 20 mg caffeine citrate (equivalent to 10 mg of caffeine base) prepared in solution by the addition of 10 mg caffeine anhydrous to 5.0 mg citric acid monohydrate, 8.3 mg sodium citrate dihydrate and Water for Injection.
Can iv caffeine be given orally?
(c) Caffeine Citrate 10mg/ml Solution for Injection is also effective when administered orally, and this route may be used alternatively without adjusting the dose.
How do you dilute caffeine citrate?
Caffeine citrate can be either used without dilution or diluted in sterile solutions for infusion such as glucose 50 mg/mL (5%), or sodium chloride 9 mg/mL (0.9%) or calcium gluconate 100 mg/mL (10%) immediately after withdrawal from the ampoule (see section 6.6).
What is caffeine citrate used for?
This medication is used for the short-term treatment of a breathing problem (apnea) in premature infants. Caffeine blocks certain proteins (adenosine receptors) which lead to improved breathing in these infants.
How long does caffeine stay in a newborn’s system?
The half-life* of caffeine is about 97.5 hours in a newborn, 14 hours in a 3-5 month old baby and 2.6 hours in a baby older than 6 months. In comparison, the half-life of caffeine in an adult is 4.9 hours.
How does caffeine work for premature babies?
Premature babies have difficulty breathing. Giving them caffeine helps regulate their breathing by stimulating the part of the brain that signals the lungs to inflate.
Is caffeine citrate a respiratory depressant?
RESULTS: Caffeine citrate is a stimulant of the respiratory and central nervous systems. It binds competitively to the receptors for adenosine A1 and A2A, causing inhibition.
Why do babies get caffeine citrate?
Caffeine citrate is presently one of the most prescribed medicines in neonatal units for apnea of prematurity. It is the first choice among all methylxanthines because of its efficacy, better tolerability and wider therapeutic index as well as longer half-life.
What is IV caffeine used for?
Caffeine citrate injection is used to treat short-term apnea of prematurity when premature babies (infants between 28 and 32 weeks gestational age) stop breathing. Apnea of prematurity is caused by the baby’s breathing centers not being fully developed.
Is there injectable caffeine?
Caffeine citrate injection is given as an infusion into a vein. A healthcare provider will give your child this injection.