What is a CF3 group called?

What is a CF3 group called?

The trifluoromethyl group is a functional group that has the formula -CF3.

What is CF3 used for?

The trifluoromethyl group (abbreviated CF3) is a component of several commonly used drugs, including the antidepressant Prozac, arthritis medication Celebrex and Januvia, used to treat diabetes symptoms.

Is trifluoromethyl polar or nonpolar?

4.1 Nonpolar trifluoromethyl-substituted α-amino acids.

Is CF3 electrophilic?

Compared to the methyl radical the CF3 radical is pyramidal (angle 107.8 °C ) with a large inversion barrier, electrophilic and also more reactive. In reaction with styrene it is 440 times more reactive.

Is CF3 a functional group?

Common methods for introducing the trifluoromethyl group (CF3 group) into organic compounds are categorized into three; 1) the use of building blocks containing CF3 group, 2) trifluoromethylation by the use of trifluoromethylating agents such as CF3-TMS, FSO2CO2Me, CF3I, etc., and 3) the transformation of a functional …

Is CF3 an electrophile?

Traditionally, the nucleophilic trifluoromethylation reaction involves an electrophile and the CF3 anion, while the electrophilic trifluoromethylation reaction involves a nucleophile and the CF3 cation.

Is CF3 a deactivator?

Therefore, CF3 is strongly deactivating and prefers to direct an incoming substituent (in this case it was a chlorine from Cl2 ) to the meta position, just like a nitro group would.

Is CCl3 a meta directing group?

-CCl3 and – Cl are the meta director.

Is CF3 an electron withdrawing group?

CF3 is VERY inductively electron-withdrawing (three fluorines on the same carbon, all quite electronegative…). Carbocations are inherently electron-deficient/electropositive. It’s unfavorable to attempt to draw electron density away from wherever there isn’t much.

What is the geometry of CF3?

In CF3+ there are 3 bond pairs too, but since Fluorine is highly electronegative, it pulls that odd electron towards it, and due to the electron clouds on the carbon of CF3+ gives rise to a tetrahedral shape, and sp3 hybridization.