How does Manganese superoxide dismutase work?
MnSOD expression is stimulated by TNF and may act as an adaptive response to protect cells from further exposure to TNF [193]. As a demonstration of this concept, overexpression of MnSOD confers protection of a variety of cell lines against apoptosis induced by tumor necrosis factor (TNF) [194].
What is superoxide dismutase good for?
As a shot, superoxide dismutase is used for treating pain and swelling (inflammation) caused by osteoarthritis, sports injuries, and rheumatoid arthritis; a kidney condition called interstitial cystitis; gout; poisoning caused by a weed-killer called paraquat; cancer; and lung problems in newborns.
What minerals are essential for the enzyme superoxide dismutase to function?
Manganese, copper and zinc are a part of the group of superoxide dismutase enzymes (MnSOD, Cu/ZnSOD), which catalyse the superoxide anion dismutation into hydrogen peroxide and oxygen. Formed hydrogen peroxide is decomposed into water and oxygen by catalase or glutathione peroxidase.
What is serum superoxide dismutase?
Superoxide dismutase (SOD) is an antioxidant enzyme that acts to degrade superoxide, a major causitive factor for oxidative stress associated with cancer, cardiovascular disease, and various other ailments.
Does superoxide dismutase contain manganese?
MnSOD is considered to be one of the most important antioxidant components of a cell. It is a homotetrameric enzyme (mol. wt 88 kDa) and requires manganese at its active center.
What is MnSOD?
In mammalian cells, manganese superoxide dismutase (MnSOD) is the essential mitochondrial antioxidant enzyme that detoxifies the free radical superoxide, the major by-product of mitochondrial respiration.
Can you supplement superoxide dismutase?
To prevent bladder inflammation A few studies support the use of superoxide dismutase injections to prevent cystitis. More research is needed. No studies support the use of oral superoxide dismutase supplements for this use.
What produces superoxide dismutase?
Human white blood cells use enzymes such as NADPH oxidase to generate superoxide and other reactive oxygen species to kill bacteria. During infection, some bacteria (e.g., Burkholderia pseudomallei) therefore produce superoxide dismutase to protect themselves from being killed.
What type of enzyme is superoxide dismutase?
Superoxide dismutases (SOD) are a group of enzymes that catalyze the dismutation of superoxide radicals (O2−) to molecular oxygen (O2) and hydrogen peroxide (H2O2), providing cellular defense against reactive oxygen species (24).
Where does superoxide dismutase come from?
Superoxide dismutase is an enzyme found in all living cells. An enzyme is a substance that speeds up certain chemical reactions in the body. The superoxide dismutase that is used as medicine is sometimes taken from cows. Some types of superoxide dismutase come from the melon, and some are made in a lab.
Is SOD an antioxidant?
Superoxide dismutases (SODs) constitute a very important antioxidant defense against oxidative stress in the body. The enzyme acts as a good therapeutic agent against reactive oxygen species-mediated diseases.