Does imipenem treat Enterococcus?
Imipenem, the first widely used carbapenem antimicrobial agent, was shown in early studies to have good in vitro activity against Enterococcus faecalis (1, 4, 5, 9, 10) but little activity against Enterococcus faecium (2).
What is the best antibiotic for Enterococcus faecalis?
Ampicillin is the drug of choice for monotherapy of susceptible E faecalis infection. For most isolates, the MIC of ampicillin is 2- to 4-fold lower than that of penicillin. For rare strains that are resistant to ampicillin because of beta-lactamase production, ampicillin plus sulbactam may be used.
Which carbapenems cover Enterococcus?
Carbapenems (imipenem, meropenem, doripenem) possess broad-spectrum in vitro activity, which includes activity against many Gram-positive, Gram-negative and anaerobic bacteria; carbapenems lack activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus and Stenotrophomonas maltophilia.
How do you treat VRE in urine?
Fosfomycin 3 grams given orally every other day for three doses has been used for VRE cystitis. In select cases, a single 3 gram dose of fosfomycin therapy may be considered. Remove or replace indwelling urinary catheters, ureteric stents, or nephrostomy tubes whenever possible.
Why is Enterococcus faecalis resistant to antibiotics?
All enterococci exhibit decreased susceptibility to penicillin and ampicillin, as well as high-level resistance to most cephalosporins and all semi-synthetic penicillins, as the result of expression of low-affinity penicillin-binding proteins.
Is imipenem and carbapenem?
Data synthesis: Imipenem, the first carbapenem, was first marketed in 1987; meropenem was introduced to the market in 1996. In general, imipenem is more active against Gram-positive cocci while meropenem is more active against Gram-negative bacilli. The agents display similar pharmacokinetics.
Should patients with VRE be isolated?
Because patients with VRE can remain colonized for long periods after discharge from the hospital, establish a system for highlighting the records of infected or colonized patients so they can be promptly identified and placed on isolation precautions upon readmission to the hospital.
What antibiotics are resistant to Enterococcus?
Which antibiotics treat Enterococcus?
If the organism is susceptible, ampicillin is the drug of choice. Vancomycin can be used if the organism is ampicillin-resistant. Linezolid or quinupristin/dalfopristin are reasonable alternatives if the enterococcus is resistant to both ampicillin and vancomycin.