How does dengue affect the cells?
Each year, the virus infects up to 100 million people and kills about 22,000, most of them children. To infect a cell, the dengue virus initially binds to the cell surface. It gains entry into the cell when it becomes enveloped by the cell membrane during the creation of a pouch-like structure known as an endosome.
How does dengue cause death?
Severe dengue happens when your blood vessels become damaged and leaky. And the number of clot-forming cells (platelets) in your bloodstream drops. This can lead to shock, internal bleeding, organ failure and even death. Warning signs of severe dengue fever — which is a life-threatening emergency — can develop quickly.
How does dengue infect host cells?
The dengue virus attaches to the surface of a host cell and enters the cell by a process called endocytosis. Once deep inside the cell, the virus fuses with the endosomal membrane and is released into the cytoplasm. The virus particle comes apart, releasing the viral genome.
How does the dengue fever affect the organism?
Dengue fever affects the body by causing a high fever and flu-like symptoms. The virus infects your blood and causes a migraine-like headache, rash, achiness, queasiness, tiredness and fever. It can affect the blood, causing mild bleeding of the gums, and you may bruise easily.
Which blood cells are affected by dengue fever?
Dengue fever can result in a drop in your white blood cell and platelet counts. The normal platelet count in the body ranges from 1.5 to 4 lacs, this can go down to as low as 20,000 to 40,000 in the case of dengue patients.
What is the death rate of dengue fever?
Background. Dengue is endemic in most parts of the tropics with a significant mortality of 1–5%.
Which organs are affected by dengue?
Based on the fact that the liver is one of the main organs affected by dengue35,36,37,38 and that lungs and heart are also important sites involved with the severe disease13,37,39,40,41, samples from all these three organs were considered.
What is the most common cause of death in dengue?
Dengue shock, fulminant hepatitis, encephalitis and acute respiratory distress syndrome were the most common causes of death. Nausea, vomiting, abdominal pain, hypotension, altered mental status, convulsion, leukocytosis, rapid fall in platelet and elevated liver enzymes were alarming signals of fatal dengue.
Is dengue hemorrhagic fever fatal?
Some patients with dengue fever go on to develop dengue hemorrhagic fever (DHF), a severe and sometimes fatal form of the disease. Around the time the fever begins to subside (usually 3–7 days after symptom onset), the patient may develop warning signs of severe disease.
Why does dengue cause leukopenia and thrombocytopenia?
This study may suggest that leukopenia in dengue fever may be caused by virus-induced destruction or inhibition of myeloid progenitor cells. Thrombocytopenia may result from by destruction of peripheral platelet or bone marrow megakaryocytes by viruses which consequently reduce the platelet production.