How is carmustine administered?
Intravenous infusion: Administer the carmustine admixture as a slow IV infusion over 2 hours or longer not to exceed a rate of 1.66 mg/m2 per minute; injection-site pain and burning may occur with infusions given over less than 2 hours. NOTE: Carmustine is not approved by the FDA for topical administration.
How is Lomustine administered?
Lomustine is given by mouth in the form of a capsule. It may also be compounded into other forms such as chewable tablets and liquid suspensions. Give lomustine with food. Wear gloves when administering this medication.
Why is carmustine given 6 weeks apart?
Since the major toxicity is delayed bone marrow suppression, blood counts should be monitored weekly for at least 6 weeks after a dose (see ADVERSE REACTIONS). At the recommended dosage, courses of BiCNU should not be given more frequently than every 6 weeks.
Can carmustine cross the blood brain barrier?
The drug, its metabolites, or both readily cross the blood–brain barrier, resulting in cerebrospinal fluid concentrations within the range of 15%–70% of plasma levels.
How often is carmustine given?
Due to the delayed and cumulative myelosuppressive effects, carmustine is usually given at intervals of at least 6 weeks. However, repeat courses of carmustine should not be administered until leukocyte and platelet counts have returned to acceptable levels.
What type of drug is carmustine?
This medication is used to treat certain types of cancer (including multiple myeloma, brain tumor, Hodgkin’s disease, non-Hodgkin’s lymphoma). Carmustine belongs to a class of drugs known as alkylating agents. It works by slowing or stopping the growth of cancer cells.
What is a long term side effect of carmustine?
Carmustine can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results. Carmustine can have long-lasting effects on your body.
What is the mechanism of action of carmustine?
Carmustine causes cross-links in DNA and RNA, leading to the inhibition of DNA synthesis, RNA production and RNA translation (protein synthesis). Carmustine also binds to and modifies (carbamoylates) glutathione reductase. This leads to cell death. Hepatic and rapid with active metabolites.
Does carmustine cause hair loss?
Hair loss is rare with carmustine. Your hair will grow back once you stop treatment with carmustine. Colour and texture may change. Use a gentle shampoo and soft brush.
What is carmustine used for?
Carmustine injection is used to treat certain types of brain tumors. Carmustine injection is also used along with prednisone to treat multiple myeloma (a type of cancer of the bone marrow).
What is carmustine used to treat?