How long does Jod-Basedow phenomenon last?
The course of Jod-Basedow hyperthyroidism often depends on the underlying thyroid disorder. Duration of the hyperthyroid state is usually, though not always, self-limited and generally resolves within 12 weeks of iodine withdrawal in patients with or without underlying thyroid pathology.
What are the effects of too much iodine?
High iodine intakes can also cause thyroid gland inflammation and thyroid cancer. Getting a very large dose of iodine (several grams, for example) can cause burning of the mouth, throat, and stomach; fever; stomach pain; nausea; vomiting; diarrhea; weak pulse; and coma.
Who is Jod-Basedow?
Jod-Basedow phenomenon occurs due to either overactivation of the entire thyroid gland or, more commonly, autonomous nodules within the gland after iodine repletion without adequate feedback control from the pituitary gland. This escape from the protective Wolff-Chaikoff effect is called the Jod-Basedow phenomenon.
What causes Wolff Chaikoff effect?
Iodine Deficiency and Iodine Excess Hypothyroidism can be caused by iodine deficiency (see Chapter 88) or iodine excess. Inorganic iodide in excess of daily doses of 500 to 1000 mcg inhibits organification of iodide, known as the Wolff-Chaikoff effect.
What is the two disadvantage of iodine?
Both too much and too little iodine can lead to goiter and other thyroid problems. For this reason, it is important to speak to a doctor before taking iodine supplements. Excessive iodine consumption can lead to similar symptoms as iodine deficiency, including thyroid dysfunction and goiter.
What are iodine symptoms?
10 Signs and Symptoms of Iodine Deficiency
- Iodine is an essential mineral commonly found in seafood.
- Swelling in the Neck.
- Unexpected Weight Gain.
- Fatigue and Weakness.
- Hair loss.
- Dry, Flaky Skin.
- Feeling Colder Than Usual.
- Changes in Heart Rate.
What are the two main effects of cretinism?
Congenital hypothyroidism, previously known as cretinism, is a severe deficiency of thyroid hormone in newborns. It causes impaired neurological function, stunted growth, and physical deformities.
Which hormone is responsible for cretinism?
Cretinism is a condition of severe physical and mental retardation due to iodine deficiency, and specifically due to deficiency of thyroid hormones during early pregnancy.
Does methimazole cause muscle pain?
Many people using this medication do not have serious side effects. Tell your doctor immediately if any of these rare but serious side effects occur: yellowing eyes/skin, dark urine, severe stomach/abdominal pain, persistent nausea/vomiting, joint/muscle pain, change in the amount of urine.
Is methimazole immunosuppressant?
The immunosuppressive effect of methimazole on cell-mediated immunity is mediated by its capacity to inhibit peroxidase and to scavenge free oxygen radicals. Clin Endocrinol (Oxf).
What is Jod-Basedow syndrome?
Jod-Basedow phenomenon From Wikipedia, the free encyclopedia Not to be confused with Basedow’s disease. The Jod-Basedow effect (also Jod-Basedow syndrome and Jod-Basedow phenomenon) is hyperthyroidism following administration of iodine or iodide, either as a dietary supplement or as iodinated contrast for medical imaging.
What is the Jod-Basedow effect?
The Jod-Basedow effect is named after “jod”, the German word for iodine, and Carl Adolph von Basedow (1799-1854) 3, the German physician who first described the effect. He also described Basedow disease, better known to the English-speaking world as Graves disease.
Does the Jod-Basedow effect occur in normal thyroid glands?
The Jod-Basedow effect does not occur in persons with normal thyroid glands who ingest extra iodine in any form. The Jod-Basedow effect is named for the German word for iodine, “Jod” (all nouns are capitalized in German), plus the name of Karl Adolph von Basedow, a German physician who first described the effect.
What is the nomenclature for Jod-Basedow?
The nomenclature “Jod-Basedow” was carried over intact from the German, rather than being translated, presumably on the erroneous assumption that “Jod” is a surname. Thus, a more informative nomenclature in English, and one that avoids the appearance of an eponym involving a nonexistent “Dr. Jod”, would be “the Basedow iodine effect”.