Is McCune-Albright syndrome malignant?

Is McCune-Albright syndrome malignant?

McCune-Albright syndrome (MAS) is defined by the triad of FD, café au lait spots, and precocious puberty or at least one of the typical hyperfunctioning endocrinopathies in almost any possible combination (2). Bone lesions observed in MAS and FD can mimic malignant processes (3).

What are the causes of central precocious puberty?

In rare cases, central precocious puberty may be caused by:

• A tumor in the brain or spinal cord (central nervous system)
• A defect in the brain present at birth, such as excess fluid buildup (hydrocephalus) or a noncancerous tumor (hamartoma)
• Radiation to the brain or spinal cord.
• Injury to the brain or spinal cord.

How do you test for McCune-Albright syndrome?

Testing and diagnosis Your child’s doctor will conduct a complete physical examination to check for cafe-au-lait spots and other symptoms of McCune-Albright syndrome. An X-ray and bone scan will reveal whether fibrous dysplasia is present and blood tests will show whether certain hormone levels are elevated.

Do cafe au lait spots mean neurofibromatosis?

Café au lait spots (CALS) are extraordinarily common; six or more lesions (at least 0.5 cm prior to puberty or 1.5 cm post puberty) are considered one of the criteria for diagnosing neurofibromatosis type I (NF1), and are also seen in a variety of other syndromes.

What are cafe au lait spots associated with?

Café au lait spots are usually present at birth, permanent, and may grow in size or increase in number over time. Cafe au lait spots are themselves benign and do not cause any illness or problems. However, they may be associated with syndromes such as Neurofibromatosis Type 1 and McCune-Albright syndrome.

Is precocious puberty life threatening?

Apart from just cutting a girl’s physical childhood short, early puberty is linked to consequences that can reverberate throughout her life. It’s linked to greater risk for breast cancer, teen pregnancy, HPV, heart disease, diabetes, and all-cause mortality, which is the risk of dying from any cause.