What are the two major functions that DNA polymerase performs?
Primary functions of DNA polymerases. DNA polymerases are a group of polymerases that catalyze the synthesis of polydeoxyribonucleotides from mono-deoxyribonucleoside triphosphates (dNTPs), performing the most fundamental functions in vivo of DNA replication, repair, and, in some cases, cell differentiation.
What are the two types of DNA repair?
The different types of DNA repair include direct repair, base excision repair, nucleotide excision repair (NER), double-strand break repair (including homologous recombination and nonhomologous end joining), and crosslink repair (Sancar et al., 2004).
What type of error does incorrect splicing cause?
Several genetic diseases may be the result of incorrect splicing. For example, mutations that cause the incorrect splicing of -globin mRNA are responsible for some cases of -thalassemia. Another example is TTP (Thrombotic Thrombocytopenic Purple). TTP is caused by ADAMTS-13 deficiency.