What does a high beta 2 globulin mean?
People with cancers of the bone marrow and blood often have high levels of B2M in their blood or urine. These cancers include multiple myeloma, lymphoma, and leukemia. High levels of B2M in cerebrospinal fluid can mean that cancer has spread to the brain and/or spinal cord.
What is considered high beta 2 microglobulin?
The amount of beta-2-microglobulin in the blood….The Revised International Staging System.
| RISS Stage Group | Factors |
|---|---|
| III | Serum beta-2 microglobulin is 5.5 (mg/L) or greater AND Cytogenetics are considered “high-risk”* AND/OR LDH levels are high |
What causes elevated beta 2 microglobulin?
Conditions associated with an increased rate of cell production or destruction, severe infections, viral infections such as CMV (cytomegalovirus), and some conditions that activate the immune system, such as inflammatory conditions and autoimmune disorders, can cause increases in beta-2 microglobulin levels, but the …
What does high beta globulin mean?
Elevated beta-globulin levels may be indicative of chronic liver or kidney disease, or chronic inflammatory diseases such as aspergillosis or avian chlamydiosis. The most common reason for elevated beta globulins in birds, which is attributable to the transferrin component, is egg production.
What is the function of β 2 microglobulin?
Impaired renal function and hyperproduction of beta 2-microglobulin are both associated with increased serum levels. A function for beta 2-microglobulin as a modulator of lymphocyte surface and as a potential regulator of the immune system is proposed.
What is the effect of β2 microglobulin on MHC I molecules?
In cytomegalovirus infection, a viral protein binds to β2 microglobulin, preventing assembly of MHC class I molecules and their transport to the plasma membrane. Mice models deficient for the β2 microglobulin gene have been engineered.