What does a high interleukin 2 receptor mean?
The serum soluble interleukin 2 receptor (sIL2R) level is elevated in patients with most types of lymphoid neoplasms, and is also elevated in patients with solid tumors or reactive conditions, such as severe inflammation.
What autoimmune diseases does high levels interleukin 2 receptor effect soluble serum?
Our experience regarding serum soluble interleukin-2 receptor (sIL-2R) measurement as a marker of lymphocyte activation consists of patients with autoimmune disease: 37 with systemic lupus erythematosus (SLE), 23 with autoimmune hepatitis (AIH), 74 with inflammatory bowel disease and six with Wegener’s granulomatosis ( …
What is soluble IL 2 receptor?
The soluble interleukin-2 receptor (sIL-2R, sIL2R, sTAC, sCD25) is a reliable biomarker for disease activity in inflammatory disorders such as sarcoidosis.
What is an interleukin-2 test for?
Test Indications: IL-2R detection may be useful in measuring T cell activation and monitoring HIV pathogenesis. Elevated IL-2R levels have clinical and prognostic significance in patients with malignant lymphoma, non-Hodgkin’s lymphoma, B cell and undifferentiated lymphomas.
Is IL 2 an inflammatory cytokine?
Interleukin 2 (IL-2), IL-10 and transforming growth factor-β (TGF-β) are well characterized, whereas IL-27, IL-35 and IL-37 represent newcomers to the spectrum of anti-inflammatory cytokines.
What is Alps syndrome?
Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes).
What is HLH disease symptoms?
Fever and enlargement of the spleen are the most common symptoms of HLH. There are many other possible symptoms, including: Enlargement of your liver. Swollen lymph nodes.
How is HLH diagnosed?
HLH can be diagnosed only with the proper tests. Blood tests include blood cell counts, liver function, infection studies, and markers of immune system activation such as ferritin and soluble IL-2 receptor levels. A bone marrow aspirate and biopsy may be performed to look for microscopic evidence of hemophagocytosis.
Which of these cells produces IL-2?
T cells
IL-2 is a typical four α helix cytokine and is produced primarily by activated CD4+ T cells, although expression by naive CD8+ T cells, dendritic cells, and thymic cells has also been reported (8, 9, 10, 11).
What does a high il2r level mean?
The serum soluble interleukin 2 receptor (sIL2R) level is elevated in patients with most types of lymphoid neoplasms, and is also elevated in patients with solid tumors or reactive conditions, such as severe inflammation.
What is the role of the IL-2 receptor in immunity?
The IL-2 – IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor IL-2 is involved in immunity, but is also important for maintenance of tolerance. The functional role of soluble IL-2R is controversial varying from activation to suppression of immunity.
Is serum sIL-2R a useful test for diagnosis of HLH?
Serum sIL-2r is a sensitive test for diagnosis of adult HLH, but is not as specific as previously reported in children. Additional studies enriched with patients without HLH who have conditions associated with T-cell activation, such as lymphoma and autoimmune lymphoproliferative syndrome, are needed.
What does HLH stand for?
In particular in diseases like hemophagocytic lymphohistiocytosis (HLH) and T-cell lymphoma’s extremely high levels are encountered and are relevant for diagnosis and prognosis, respectively [1], [2].