What does a PPAR agonist do?

What does a PPAR agonist do?

PPAR agonists are drugs which act upon the peroxisome proliferator-activated receptor. They are used for the treatment of symptoms of the metabolic syndrome, mainly for lowering triglycerides and blood sugar.

What is the function of PPAR?

PPARs are members of the supergene family of nuclear receptors that function as transcription factors regulating the expression of genes involved in cellular intermediary metabolism and inflammation.

What is the meaning of PPARs?

Abstract. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. PPAR ? is mainly expressed in the liver, where it activates fatty acid catabolism.

Where are PPARs located?

ISOFORMS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS γ1 – expressed in virtually all tissues, including heart, muscle, colon, kidney, pancreas, and spleen. γ2 – expressed mainly in adipose tissue (30 amino acids longer).

Is PPAR a transcription factor?

PPARs are a class of ligand-activated transcription factors belonging to the superfamily of receptors for steroid and thyroid hormones, retinoids and vitamin D that control the expression of a large number of genes involved in lipid and carbohydrate metabolism and in the regulation of cell proliferation.

How are PPARs activated?

Peroxisome proliferator-activated receptors (PPARs) are transcription factors, activated by binding metabolic ligands, which exert their effects at the level of DNA to alter gene expression.

Is Metformin a PPAR gamma agonist?

Metformin, although not a PPAR agonist, is also commonly used in the treatment of type 2 diabetes. Here, metformin was found to have no effect on bone cell function. Taken together, these data suggest that PPAR-γ agonists may enhance bone loss via increased adipogenesis at the expense of osteoblast formation.

Is PPAR Gamma transcription factor?

PPAR-γ: a thrifty transcription factor.