What does C1-inhibitor do?
C1-inhibitor (C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system to prevent spontaneous activation but also as the major regulator of the contact system.
How do you test for low C1 inhibitors?
Your doctor can order blood tests to check your complement protein levels. One of these tests is the C1 esterase inhibitor test or C1-INH test. The C1-INH test can help your doctor determine if you have enough C1-INH.
What is C1-inhibitor deficiency?
Background. Acquired angioedema due to C1-inhibitor (C1-INH) deficiency (AAE-C1-INH) is a serious condition that may result in life-threatening asphyxiation due to laryngeal edema. It is associated with malignant B-cell lymphoma and other disorders.
What is C1 blood test?
The test checks the level of a substance called C1 esterase inhibitor in your blood. This substance is important in regulating the immune system. A very low level of C1 esterase inhibitor would suggest you have an inherited problem affecting how much of this substance your body is able to produce.
What type of doctor would treat angioedema?
Hereditary Angioedema Doctor: Building Your Care Team. Hereditary angioedema (HAE) is a rare genetic disorder that causes swelling in the face, throat, gastrointestinal tract, and other parts of your body. Your healthcare team should feature a doctor who has treated HAE, usually an allergist-immunologist.
Where does C1 inhibitor Come From?
C1-INH can be purified from human plasma, and plasma derived C1-INH has been available for 20 years for the treatment of C1-INH-deficient patients. Several expression systems of C1-INH have been described and a recombinant human C1-INH has been developed using transgenic rabbits.
What is a normal C1 inhibitor level?
C1 inhibitor
| Test Identifier Information | |
|---|---|
| Contact Phone Number | (03)3640334 | x80334 |
| Test Availability | Batched weekly |
| Turnaround Time | 1 – 2 weeks |
| Reference Interval | Normal range >18g/L |
What is a C1 blood test for?