What does complete response mean in multiple myeloma?

What does complete response mean in multiple myeloma?

Definition of complete response. When HDT was introduced in the treatment of MM, CR was first defined as the disappearance of the M-component on serum and/or urine electrophoresis with 5% or fewer plasma cells on bone marrow aspiration.

What is partial response in multiple myeloma?

Partial response (PR) PR is defined as having a ≥50% reduction in serum monoclonal protein and a reduction in 24-hour urine monoclonal protein of ≥90% or to <200 mg/24 h. Additionally, a ≥50% reduction in the size of soft tissue plasmacytomas is required if the patient had plasmacytoma at baseline.

What is a deep response?

Science of deep response Deep response, or undetectable minimal residual disease (uMRD), is defined as <1 tumour cell per 104 white cells. It is a powerful prognostic tool that demonstrates an inverse relationship with patient outcomes.

What is very good partial response?

Since even with HDT, CR remained relatively rare, our group has developed the concept of very good partial response (VGPR) which is defined by at least 90% reduction of the monoclonal component and which was significantly correlated with a longer OS in two consecutive trials on HDT.

What is the difference between complete response and complete remission?

The disappearance of all signs of cancer in response to treatment. This does not always mean the cancer has been cured. Also called complete remission.

Is M protein the same as IgM?

M proteins are grouped by what kind of heavy and light chains they have. There are five kinds of heavy chains, called IgG, IgA, IgD, IgM, and IgE. There are two types of light chains, called kappa and lambda. The most common type of M protein in myeloma is IgG.

What is a stringent complete response?

Among the definitions is that of stringent complete response, defined as those patients “achieving complete response for whom the involved free-light chain reduced sufficiently to normalize the free-light chain ratio in the absence of monoclonal bone marrow plasma cells as assessed my immunohistochemistry or …

What does Major molecular response mean?

A major molecular response (MMR) means that the amount of BCR-ABL gene in your blood or bone marrow is 1/1000th (or less) of what’s expected in someone with untreated CML.

What is molecular remission?

Sometimes the terms complete molecular remission or complete molecular response is used. This means that leukemia cells cannot be found in the bone marrow even with very sensitive lab tests. You might also hear the term no evidence of disease (NED). Being in remission doesn’t necessarily mean you’re cured.

What is duration of response?

Duration of response is the time from response (R) to progression/death (P/D). The existing statistical procedures for DOR are valid when certain model assumptions are correctly specified.

What is considered a good response to chemo?

Complete response – all of the cancer or tumor disappears; there is no evidence of disease. A tumor marker (if applicable) may fall within the normal range. Partial response – the cancer has shrunk by a percentage but disease remains.

What is a good partial response to multiple myeloma (MM)?

Very good partial response of multiple myeloma or plasma cell leukemia is characterized by serum and urine M-protein detectable by immunofixation but not on electrophoresis, or at least 90% reduction in serum M-protein and urine M-protein level < 100 mg/24 hours.

Is complete response impacted by high-dose therapy in multiple myeloma?

In multiple myeloma (MM), the impact of complete response (CR) could be shown only after introduction of high-dose therapy plus autologous stem cell transplantation (ASCT).

How does multiple myeloma affect the body’s immune system?

In the bone marrow, myeloma cells crowd out healthy blood cells, leading to fatigue and an inability to fight infections. The myeloma cells continue trying to produce antibodies, as healthy plasma cells do, but the myeloma cells produce abnormal antibodies that the body can’t use.

What is the definition of cytomegalovirus (CR) in the treatment of multiple myeloma?

When HDT was introduced in the treatment of MM, CR was first defined as the disappearance of the M-component on serum and/or urine electrophoresis with 5% or fewer plasma cells on bone marrow aspiration. 13

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