What does P-selectin bind to?

What does P-selectin bind to?

P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets.

What is vascular cell adhesion?

The vascular cell adhesion molecule VCAM-1 was originally identified as a cytokine-inducible adhesion molecule on human endothelial cells, mediating the binding to leukocytes and melanoma cells (178,203,204). VCAM-1 is a ligand for the α4β1 integrin (VLA-4) and binds weakly to α4β7 (102,205–207).

Is VCAM an integrin?

VCAM-1 is a ligand for the α4β1 integrin (VLA-4) and binds weakly to α4β7 (102,205–207). A single VCAM-1 gene gives rise through alternative splicing to distinct isoforms (204, 208–211). The major form of VCAM-1 in humans contains seven Ig domains of which domains 1–3 are homologous to domains 4–6 (204).

Is P-selectin and integrin?

P-selectin-mediated adhesion enables chemokine- or platelet-activating factor-triggered activation of β2 integrins, which stabilizes adhesion.

Is P-selectin a protein?

P-selectin (PADGEM, GMP-140, CD62) is a transmembrane protein specific to alpha granules of platelets and Weibel-Palade bodies of endotheial cells. Upon stimulation of these cells, P-selectin is translocated to the plasma membrane where it functions as a receptor for monocytes and neutrophils.

What is VCAM immunology?

VCAM-1 is a key cell adhesion molecule involved in inflammation that is closely implicated in various immunological disorders, including rheumatoid arthritis, asthma, transplant rejection, and cancer (Table 1). VCAM-1 is a potential therapeutic target in immunological disorders and cancer.

What are ICAMs in immunology?

In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events.

What does Pecam 1 bind to?

Heterophilic binding partners of PECAM-1 include the integrin αVβ3,70–72 CD38,73 and the neutrophil-specific CD17774; however, the physiological relevance of these interactions to platelets is currently not clear.