What drugs are taxanes?

What drugs are taxanes?

Antineoplastics, Antimicrotubular (Taxanes)

  • docetaxel.
  • Oraxol.
  • paclitaxel.
  • paclitaxel/encequidar.
  • Taxol.
  • Taxotere.

How many taxanes are there?

Two taxanes are currently available for the treatment of advanced breast cancer—paclitaxel (Taxol) and docetaxel (Taxotere). These agents have different and specific mechanisms of action, and this article will focus on the most extensively studied of them, paclitaxel.

Is cisplatin a taxane?

PURPOSE Cisplatin plus fluorouracil (PF) induction chemotherapy has been compared with taxane (docetaxel or paclitaxel), cisplatin, and fluorouracil (Tax-PF) in randomized trials in locoregionally advanced head and neck cancers (LAHNCs).

How do taxanes act as anticancer drugs?

The “taxanes” are a class of anticancer drugs that act by binding to tubulins/microtubules which have a key role in cell division [1, 2]. The binding of taxanes to β-tubulin promotes the assembly of microtubules and simultaneously inhibits disassembly, thereby stabilizing microtubule dynamics [1, 2].

What are taxanes made from?

Taxanes are a class of diterpenes. They were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. Cabazitaxel was FDA approved to treat hormone-refractory prostate cancer.

Is Abraxane a taxane?

Abraxane (chemical name: albumin-bound or nab-paclitaxel) is a different form of paclitaxel than Taxol (chemical name: paclitaxel). Both medicines are taxanes, a powerful type of chemotherapy medicine that can stop cancer cells from repairing themselves and making new cells.

What are taxanes for?

A type of drug that blocks cell growth by stopping mitosis (cell division). Taxanes interfere with microtubules (cellular structures that help move chromosomes during mitosis). They are used to treat cancer. A taxane is a type of mitotic inhibitor and a type of antimicrotubule agent.

Is Taxol platinum-based?

Taxol as second-line treatment in patients with advanced ovarian cancer after platinum-based first-line chemotherapy.

What is platinum taxane chemotherapy?

Chemotherapy uses drugs that target and kill cancer cells. After surgery, most women with ovarian cancer get a platinum-based drug and a taxane as a first-line chemotherapy combined treatment.

What drugs are anthracyclines?

Anthracycline chemotherapy medicines are:

  • Adriamycin (chemical name: doxorubicin)
  • Ellence (chemical name: epirubicin)
  • Doxil (chemical name: doxorubicin)
  • daunorubicin (brand names: Cerubidine, DaunoXome)
  • mitoxantrone (brand name: Novantrone)

What uses might taxanes have as a therapeutic drug?

Taxanes are commonly used in the treatment of various solid tumors, such as breast cancer, non-small-cell lung cancer and prostate cancer. They work by binding to the microtubule β-tubulin subunit and interfering with microtubule depolymerization, which inhibits cell division [1,2].

Is nab-paclitaxel a taxane?

nab-paclitaxel: a novel formulation of taxane for treatment of breast cancer.

What is a taxane drug?

Taxanes are a class of diterpenes. They were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents.

What is the difference between taxanes and taxoids?

Taxanes or taxoids are a subclass of mitotic inhibitors, meaning that they were originally derived from plants which are part of the genus “Taxus,” a group which includes small trees and shrubs in the yew family. Taxanes and taxoids are generally defined identically, with slight variation depending upon the reference.

What is the difference between taxane and docetaxel?

The taxanes in clinical use include paclitaxel (Taxol, Bristol-Myers Squibb) and docetaxel (Taxotere, Sanofi-Aventis). Paclitaxel is a natural product isolated from the bark of the Western yew tree (Taxus brevifolia) and docetaxel is a semisynthetic analog (Wani et al., 1971).

Why are taxanes difficult to make into medicine?

Taxanes present difficulties in formulation as medicines because they are poorly soluble in water. As their name suggests, taxanes were first derived from natural sources, but some have been semisynthesized. Paclitaxel was originally derived from the Pacific yew tree.

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