What genetic mutation causes diabetes?

What genetic mutation causes diabetes?

The causes of type 1 diabetes are unknown, although several risk factors have been identified. The risk of developing type 1 diabetes is increased by certain variants of the HLA-DQA1, HLA-DQB1, and HLA-DRB1 genes. These genes provide instructions for making proteins that play a critical role in the immune system.

What is TCF7L2 mutation?

Entrez Gene Summary for TCF7L2 Gene This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes.

Could a mutation in DNA cause diabetes?

Type 2 diabetes is caused by both genetic and environmental factors. Scientists have linked several gene mutations to a higher diabetes risk. Not everyone who carries a mutation will get diabetes. However, many people with diabetes do have one or more of these mutations.

What is the risk allele in TCF7L2?

The risk T allele of rs7903146 in the TCF7L2 gene is strongly associated with an increased risk of T2DM and this effect is additive. Approximately 10% of population has two copies of the risk T allele and these individuals are twice as likely to develop T2DM as compared with individuals with no risk alleles [24].

Is type 2 diabetes genetic NCBI?

Type 2 Diabetes which happens to be the non-insulin dependent one is the most common form of the disease and is caused by the interaction between genetic and non-genetic factors. Despite conflicting results, numerous studies have identified genetic and non-genetic factors associated with this common type of diabetes.

What chromosome is affected by type 2 diabetes?

Genome scans in families with type 2 diabetes identified a putative locus on chromosome 20q.

What is the function of the FTO protein?

FTO is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylase, which are non-heme iron-containing proteins. Recombinant FTO protein was first discovered to catalyze demethylation of 3-methylthymine in single-stranded DNA, and 3-methyluridine in single-stranded RNA, with low efficiency.

How can you prevent genetic diabetes?

Advertisement

1. Lose extra weight. Losing weight reduces the risk of diabetes.
2. Be more physically active. There are many benefits to regular physical activity.
3. Eat healthy plant foods. Plants provide vitamins, minerals and carbohydrates in your diet.
4. Eat healthy fats.
5. Skip fad diets and make healthier choices.

Is there a gene for type 1 diabetes?

There’s no diabetes gene that gets turned on or off to give you type 1. Instead, a bunch of them play a role, including a dozen or so that have the biggest say: the HLA genes. They make proteins your immune system uses to keep you healthy.

What is rs7903146?

The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity.