What is a trephine biopsy?

What is a trephine biopsy?

TREPHINE BIOPSY  Removal of a small core of BM under local anesthetic. It is used to assess BM structure, the no. & distribution of all types of blood cell .  Trephine biopsy is 1-2cm long 2-3mm in dia. Of the marrow containing bone taken by rotating specialized needle under pressure 2 3. BONE MARROW ASPIRATION 3 4.

What is the role of trephine biopsy in the diagnosis of multiple myeloma?

Bone marrow aspiration and trephine biopsy should be regarded as complementary investigations in suspected multiple myeloma. A trephine biopsy is essential for diagnosis in some patients.

When is a bone marrow trephine biopsy indicated in the treatment of osteoporosis?

Patients with early stage disease do not require active treatment and bone marrow biopsy is not essential for management. However, a bone marrow trephine biopsy is indicated in patients in whom treatment is necessary, either those with more advanced disease or younger patients in whom intensive treatment is planned.

What are the indications for a trephine biopsy in lymphoproliferative disorders?

Unexplained pancytopenia and an unexplained leucoerythroblastic blood film are indications for a trephine biopsy because they are likely to indicate bone marrow infiltration or fibrosis. Some controversy surrounds the role of the trephine biopsy in lymphoproliferative disorders.