What is abiraterone acetate made of?
Abiraterone acetate is a sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo into abiraterone. Used for treatment of metastatic castrate-resistant prostate cancer.
How does abiraterone acetate work?
Abiraterone acetate works by inhibiting specific “enzymes” in your adrenal glands that are responsible for making androgens. For this reason, there is an increased risk of over production of mineralcorticosteroids in your body while on abiraterone acetate.
What is the mechanism of action of abiraterone?
Mechanism of Action Abiraterone acetate is converted in vivo to abiraterone, an androgen biosynthesis inhibitor, that inhibits 17 a-hydroxylase/C17,20-lyase (CYP17). This enzyme is expressed in testicular, adrenal, and prostatic tumor tissues and is required for androgen biosynthesis.
Who manufactures abiraterone acetate?
ZYTIGA® is marketed by Janssen Biotech, Inc. ZYTIGA® (abiraterone acetate) is indicated in combination with prednisone for the treatment of patients with: metastatic castration-resistant prostate cancer (CRPC)
What are the side effects of abiraterone?
Side Effects
- Bladder pain.
- bloating or swelling of the face, arms, hands, lower legs, or feet.
- bloody or cloudy urine.
- bone pain or fracture.
- chest pain or discomfort.
- decreased urine.
- difficult, burning, or painful urination.
- fast, pounding, or irregular heartbeat or pulse.
What are side effects of Zytiga?
The most common side effects of ZYTIGA® include:
- Feeling very tired.
- Joint pain.
- High blood pressure.
- Nausea.
- Swelling in your legs or feet.
- Low blood potassium levels.
- Hot flushes.
- Diarrhea.
Where is abiraterone metabolized?
Abiraterone acetate
| Clinical data | |
|---|---|
| Bioavailability | Unknown, but may be 50% at most on empty stomach |
| Protein binding | Abiraterone: ~99.8% (to albumin and α1-AGp ) |
| Metabolism | Esterases, CYP3A4, SULT2A1 |
| Metabolites | Abiraterone, others |
Is abiraterone a chemotherapy drug?
Zytiga (abiraterone acetate) is a type of hormone therapy that is used along with prednisone to treat men with prostate cancer that has spread to other parts of the body (metastasized). Despite being used to treat cancer, Zytiga is not a form of chemotherapy.
Is Abiraterone a chemotherapy drug?
Can you drink alcohol while taking Abiraterone?
The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of abiraterone. is best to use birth control while being treated with abiraterone.
Does Zytiga damage liver?
Liver damage, severe liver toxicity (when harmful levels of the drug build up in your liver), and liver failure were reported as side effects in clinical studies of Zytiga. Symptoms of liver problems include jaundice (yellowing of your skin or eyes), urine that’s darker than normal, stomach pain, nausea, and vomiting.
Is abiraterone a chemo drug?