What is amikacin used to treat?
Amikacin injection is used to treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and infections of the blood, abdomen (stomach area), lungs, skin, bones, joints, and urinary tract.
How long is amikacin used for?
The recommended dose in prematures is 7.5 mg/kg in every 12 hours (see sections 4.4 and 5.2). The usual duration of treatment is 7 to 10 days. The total daily dose by all routes of administration should not exceed 15-20 mg/kg/day.
Is amikacin used for UTI?
Amikacin therapy administered once daily to outpatients can be a feasible treatment option for mild to moderate urinary tract infections caused by ESBL-EC, in cases of adverse drug reactions to carbapenem or in settings with limited resources, provided that patients are closely monitored for renal function and …
Does amikacin need to be refrigerated?
Amikacin Sulfate Injection USP is supplied as a clear colorless to light straw colored solution which requires no refrigeration. At times the solution may become a very pale yellow; this does not indicate a decrease in potency.
How many milligrams of amikacin are in a 2 ml vial?
The 500 mg per 2 mL vial and 1 gram per 4 mL vial contains per each mL: 250 mg amikacin (as the sulfate), 0.66% sodium metabisulfite, 2.5% sodium citrate dihydrate, water for injection qs, with pH adjusted to 4.5 with sulfuric acid. Amikacin, an aminoglycoside, binds to the prokaryotic ribosome, inhibiting protein synthesis in susceptible bacteria.
What are the side effects of amikacin?
Amikacin side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: hearing loss, or a roaring sound in your ears;
How much Amikacin can you take for urinary tract infection?
When amikacin is indicated in uncomplicated urinary tract infections, a dose of 250 mg twice daily may be used. Intramuscular Administration for Patients with Impaired Renal Function: Whenever possible, serum amikacin concentrations should be monitored by appropriate assay procedures.
What is amikacin sulfate injection made of?
Amikacin sulfate injection, USP is a semi-synthetic aminoglycoside antibiotic derived from kanamycin. It is O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→6)]-N3-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine sulfate (1:2).