What is an NS5?
Nonstructural protein 5 (NS5) refers to two viral proteins found in the hepatitis C virus: NS5A.
What is NS5 gene?
Nonstructural protein 5 (NS5) is essential for the replication of the flaviviral RNA genome4,5,6. The N-terminal portion of NS5 contains a methyltransferase (MT), followed by a short linker that connects to the RNA-dependent RNA polymerase (RdRp).
What is the function of the Zika virus?
The Flavivirus Zika virus (ZIKV) is the causal agent of neurological disorders like microcephaly in newborns or Guillain-Barre syndrome. Its NS5 protein embeds a methyltransferase (MTase) domain involved in the formation of the viral mRNA cap.
When did the Zika virus start?
Zika virus was first discovered in 1947 and is named after the Zika Forest in Uganda. In 1952, the first human cases of Zika were detected and since then, outbreaks of Zika have been reported in tropical Africa, Southeast Asia, and the Pacific Islands. Zika outbreaks have probably occurred in many locations.
Is Zika virus RNA or DNA?
Zika virus is a single-stranded RNA virus of the Flaviviridae family, genus Flavivirus. Zika virus is transmitted to humans primarily through the bite of an infected Aedes species mosquito (Ae.
What is the treatment of Zika virus?
There is no specific treatment for infection with the Zika virus. To help relieve symptoms, get plenty of rest and drink plenty of fluids to prevent dehydration. The over-the-counter (OTC) medication acetaminophen (Tylenol, others) may help relieve joint pain and fever.
Was the Zika virus a pandemic?
Epidemic and pandemic are terms primarily distinguished in terms of spread of contagious, infectious, or viral illness. An epidemic is limited to one specific region while a pandemic has a worldwide spread. Zika virus disease is an epidemic which was reported in Brazil in Feb., 2016.
Is Dengue an RNA virus?
Dengue Virus Genome and Structure The dengue virus genome is a single strand of RNA. It is referred to as positive-sense RNA because it can be directly translated into proteins. The viral genome encodes ten genes (Figure 2). The genome is translated as a single, long polypeptide and then cut into ten proteins.
What is Giga virus?
Zika virus is a mosquito-borne illness that is spread by the Aedes mosquito, the same species that transmits the dengue and chikungunya viruses. Unlike malaria-carrying mosquitoes, Aedes is most active during the day.
How long does the Zika virus last?
Symptoms are generally mild and include fever, rash, conjunctivitis, muscle and joint pain, malaise or headache. Symptoms typically last for 2–7 days. Most people with Zika virus infection do not develop symptoms.