What is CIVD?

What is CIVD?

Common variable immunodeficiency (CVID) is a primary immune deficiency disease characterized by low levels of protective antibodies and an increased risk of infections. Although the disease usually is diagnosed in adults, it also can occur in children.

Is common variable immunodeficiency an autoimmune disease?

Immune cells can accumulate in other organs, forming small lumps called granulomas. Approximately 25 percent of people with CVID have an autoimmune disorder, which occurs when the immune system malfunctions and attacks the body’s tissues and organs.

What does Hypogammaglobulinemia mean?

Hypogammaglobulinemia refers to a laboratory finding (low immunoglobulin G, or IgG) that may be asymptomatic if mild or may be associated with a number of clinical entities with varied causes and manifestations if more extreme.

Is Hypogammaglobulinemia an autoimmune disease?

Many autoimmune diseases have been described in the course of hypogammaglobulinemia, such as cytopenias, inflammatory bowel disease, seronegative arthritis, Sjögren’s syndrome, uveitis, vasculitis, and vitiligo (22,23).

What causes hypogammaglobulinemia?

Hypogammaglobulinemia may result from a variety of primary genetic immune system defects, such as common variable immunodeficiency, or it may be caused by secondary effects such as medication, blood cancer, or poor nutrition, or loss of gamma globulins in urine, as in nonselective glomerular proteinuria.

Is Hypergammaglobulinemia serious?

Dangers to people with hypergammaglobulinemia High levels of gamma globulins in the blood are dangerous because these can lead to an increased likelihood of contracting viruses and infections. Hypergammaglobulinemia leads to increased vulnerability to: anemia. respiratory infections.

Can CVID be cured?

CVID has no cure. With ongoing treatment, many people with the disorder live active and fulfilling lives. In some cases, complications of CVID such as lung damage or cancer may affect life expectancy.

What can cause hypogammaglobulinemia?

Is CVID a rare disease?

CVID is the most common of all the primary immunodeficiency rare diseases. It is found in about one in 25,000 people. It is most often diagnosed in adults. Only about 20% of those affected with this disorder are diagnosed as children.