What is Cribriform architecture?
Cribriform architecture is an independent predictor for metastasis-free survival and has better discriminative value for clinicopathological outcome than Gleason score. Therefore, reporting cribriform architecture might add value in risk stratification of Gleason score 8 prostate cancer patients.
What is Cribriform morphology?
Cribriform, derived from the Latin word cribrum (i.e. sieve), was introduced by Gleason to describe glands composed of a solid sheet with perforations or lumina. Cribriform morphology has a worse prognosis compared with the other, non-cribriform, GP4 morphologies.
What is Cribriform pattern prostate cancer?
Following a virtual meeting, convened to discuss selected images and diagnostic criteria, the following definition for cribriform pattern in prostate cancer was approved: “A confluent sheet of contiguous malignant epithelial cells with multiple glandular lumina that are easily visible at low power (objective …
What does Gleason pattern 4 mean?
In the new system, Grade Group 2 (3+4) is more favorable risk than Grade Group 3 (4+3). The difference is, when pattern 4 is listed first, it means a greater proportion of 4 than 3. This indicates the disease is evolving in an aggressive direction.
What is Cribriform DCIS?
Cribriform DCIS: There are gaps between cancer cells in the affected breast ducts (like the pattern of holes in Swiss cheese). SolidLarger Version. Solid DCIS: Cancer cells completely fill the affected breast ducts.
How serious is a Gleason score of 9?
The lowest Gleason score is 6, which is a low-grade cancer. A Gleason score of 7 is a medium-grade cancer, and a score of 8, 9, or 10 is a high-grade cancer. A lower-grade cancer grows more slowly and is less likely to spread than a high-grade cancer.
What is focal high-grade prostatic intraepithelial neoplasia?
High-grade prostatic intraepithelial neoplasia (HGPIN) is an abnormality of prostatic glands and believed to precede the development of prostate adenocarcinoma (the most common form of prostate cancer). It may be referred to simply as prostatic intraepithelial neoplasia (PIN).
What is a Gleason score of 7?
A Gleason score of 7 is a medium-grade cancer, and a score of 8, 9, or 10 is a high-grade cancer. A lower-grade cancer grows more slowly and is less likely to spread than a high-grade cancer.
What is removed in a prostatectomy?
The main type of surgery for prostate cancer is a radical prostatectomy. In this operation, the surgeon removes the entire prostate gland plus some of the tissue around it, including the seminal vesicles.
What is solid Cribriform?
A “cribriform” pattern has gaps between the cancer cells within the duct, with an appearance similar to the ‘holes in swiss cheese’ or perhaps ‘ripples’. A cribriform pattern is consistent with a low or medium grade DCIS.
What does RCB II mean?
RCB index was classified as: RCB-I (minimal burden), RCB-II (moderate burden) or RCB-III (extensive burden).